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Titolo:
THE DISTRIBUTION OF ANTIBIOTIC-RESISTANCE PATTERNS WITHIN STREPTOMYCETES AND THEIR USE IN SECONDARY METABOLITE SCREENING
Autore:
PHILLIPS L; WELLINGTON EMH; REES SB;
Indirizzi:
UNIV WARWICK,DEPT BIOL SCI COVENTRY CV4 7AL W MIDLANDS ENGLAND UNIV WARWICK,DEPT BIOL SCI COVENTRY CV4 7AL W MIDLANDS ENGLAND ICI AGROCHEM PLC BRACKNELL RG12 6EY BERKS ENGLAND
Titolo Testata:
Journal of industrial microbiology
fascicolo: 1, volume: 13, anno: 1994,
pagine: 53 - 62
SICI:
0169-4146(1994)13:1<53:TDOAPW>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-CLUSTER; DETERMINANTS; METHYLATION; CLONING;
Keywords:
STREPTOMYCETE ECOLOGY; METABOLITE SCREENING; CLUSTER ANALYSIS; ANTIBIOTIC RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
L. Phillips et al., "THE DISTRIBUTION OF ANTIBIOTIC-RESISTANCE PATTERNS WITHIN STREPTOMYCETES AND THEIR USE IN SECONDARY METABOLITE SCREENING", Journal of industrial microbiology, 13(1), 1994, pp. 53-62

Abstract

A collection of 169 streptomycetes representing natural isolates and type strains were examined for resistance phenotypes to 11 antibiotics. A total of 84 profiles were obtained with 18 patterns being repeatedin two or more strains. The most common pattern was resistance to penicillin in an otherwise sensitive phenotype and accounted for 51 strains. This data was used to cluster the strains and groups defined were examined for correlation with bioactivity. Antibiotic producers were found in clusters 1, 2, 4 and 5-10. Certain strains in these areas werehighly bioactive and typically had multiple resistances. Almost half of the collection of strains examined grouped in cluster 3, and were characterized as having a sensitive phenotype and virtually no biological activity in agrochemical screens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 21:20:15