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Titolo:
INDUCED GENE-EXPRESSION OF THE HYPUSINE-CONTAINING PROTEIN EUKARYOTICINITIATION-FACTOR 5A IN ACTIVATED HUMAN T-LYMPHOCYTES
Autore:
BEVEC D; KLIER H; HOLTER W; TSCHACHLER E; VALENT P; LOTTSPEICH F; BAUMRUKER T; HAUBER J;
Indirizzi:
SANDOZ GMBH,RES INST,BRUNNER STR 59 A-1235 VIENNA AUSTRIA SANDOZ GMBH,RES INST A-1235 VIENNA AUSTRIA MAX PLANCK INST BIOCHEM D-82152 MARTINSRIED GERMANY UNIV VIENNA,DEPT DERMATOL,DIV IMMUNODERMATOL & INFECT DIS A-1090 VIENNA AUSTRIA UNIV VIENNA,DEPT INTERNAL MED 1,DIV HEMATOL A-1090 VIENNA AUSTRIA UNIV VIENNA,VIENNA INT RES COOPERAT CTR A-1235 VIENNA AUSTRIA
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 23, volume: 91, anno: 1994,
pagine: 10829 - 10833
SICI:
0027-8424(1994)91:23<10829:IGOTHP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA; POSTTRANSLATIONAL FORMATION; CYCLOSPORINE-A; FACTOR EIF-4D; REV; PURIFICATION; TRANSLATION; INDUCTION; SEQUENCE; BINDING;
Keywords:
T CELL ACTIVATION; T-CELL ANTIGEN RECEPTOR; PRIMARY HUMAN LYMPHOCYTES; HUMAN IMMUNODEFICIENCY VIRUS REV PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
D. Bevec et al., "INDUCED GENE-EXPRESSION OF THE HYPUSINE-CONTAINING PROTEIN EUKARYOTICINITIATION-FACTOR 5A IN ACTIVATED HUMAN T-LYMPHOCYTES", Proceedings of the National Academy of Sciences of the United Statesof America, 91(23), 1994, pp. 10829-10833

Abstract

The hypusine-containing protein eukaryotic initiation factor 5A (eIF-5A) is a cellular cofactor critically required for the function of theRev transactivator protein of human immunodeficiency virus type 1 (HIV-1). eIF-5A localizes in the nuclear and cytoplasmic compartments of mammalian cells, suggesting possible activities on the level of regulated mRNA transport and/or protein translation. In this report we show that eIF-5A gene expression is constitutively low but inducible with T-lymphocyte-specific stimuli in human peripheral blood mononuclear cells (PBMCs) of healthy individuals. In contrast, eIF-5A is Constitutively expressed at high levels in human cell lines as well as in various human organs. Comparison of eIF-5A levels in the PBMCs of uninfected and HIV-1-infected donors shows a significant upregulation of eIF-5A gene expression in the PBMCs of HIV-1 patients, compatible with a possible role of eIF-5A in HIV-1 replication during T-cell activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 09:03:17