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Titolo:
NEWER AND OLDER ANTIPSYCHOTICS - A COMPARATIVE REVIEW OF APPROPRIATE USE
Autore:
MORTIMER AM;
Indirizzi:
W LONDON HLTHCARE NATL HLTH SERV TRUST,UXBRIDGE RD SOUTHALL UB1 3EU MIDDX ENGLAND CHARING CROSS & WESTMINSTER MED SCH LONDON ENGLAND
Titolo Testata:
CNS DRUGS
fascicolo: 5, volume: 2, anno: 1994,
pagine: 381 - 396
SICI:
1172-7047(1994)2:5<381:NAOA-A>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
D2-DOPAMINE RECEPTOR OCCUPANCY; POSITRON EMISSION TOMOGRAPHY; NAIVE SCHIZOPHRENIC-PATIENTS; DOUBLE-BLIND MULTICENTER; D2 DOPAMINE-RECEPTORS; RAPID TRANQUILIZATION; BEHAVIORAL-DISORDERS; NEGATIVE SYMPTOMS; TEMPORAL-LOBE; HALOPERIDOL;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
99
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Mortimer, "NEWER AND OLDER ANTIPSYCHOTICS - A COMPARATIVE REVIEW OF APPROPRIATE USE", CNS DRUGS, 2(5), 1994, pp. 381-396

Abstract

The mechanism of action of older antipsychotics, without exception, involves blockade of dopamine D-2-receptors. This is the main evidence in support of the dopamine hypothesis of schizophrenia. Because of theshortcomings of older antipsychotics, newer 'atypical' antipsychoticshave been developed. These agents have novel mechanisms of action. They are active in animal models of psychosis, but do not induce Parkinsonian-like effects in animals. The existence of alternative mechanismsof action of some antipsychotics suggests that the dopamine hypothesis of schizophrenia requires modification. There is little evidence that any one older antipsychotic is superior to any other. With the exception of clozapine, the evidence that any new drug is superior in antipsychotic efficacy to the older drugs is somewhat limited. However, theadverse effect profile of the newer agents is more acceptable. The place of atypical antipsychotics in the overall treatment of schizophrenia is not yet entirely clear. In clinical practice, drug choice is a complex issue. It depends on a combination of patient, drug and illnessfactors. In particular, adherence to a medication regimen is crucial to therapeutic success. Furthermore, cost has become increasingly relevant to the choice of treatment.

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Documento generato il 26/01/20 alle ore 01:09:18