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Titolo:
THE EFFECT OF FLUORIDE THERAPY ON BLOOD-CHEMISTRY PARAMETERS IN OSTEOPOROTIC FEMALES
Autore:
JACKSON R; KELLY S; NOBLITT T; ZHANG W; DUNIPACE A; LI Y; STOOKEY G; KATZ B; BRIZENDINE E; FARLEY S; BAYLINK D;
Indirizzi:
INDIANA UNIV,SCH DENT,ORAL HLTH RES INST,415 LANSING ST INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT MED,DIV BIOSTAT INDIANAPOLIS IN 46202 LOMA LINDA UNIV,DEPT MED LOMA LINDA CA 92357 LOMA LINDA UNIV,JERRY L PETTIS MEM VET HOSP LOMA LINDA CA 92357
Titolo Testata:
Bone and mineral
fascicolo: 1, volume: 27, anno: 1994,
pagine: 13 - 23
SICI:
0169-6009(1994)27:1<13:TEOFTO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SISTER-CHROMATID EXCHANGES; DENTAL FLUOROSIS; PREVALENCE;
Keywords:
FLUORIDE; PHARMACOLOGY; GENOTOXICITY; OSTEOPOROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
R. Jackson et al., "THE EFFECT OF FLUORIDE THERAPY ON BLOOD-CHEMISTRY PARAMETERS IN OSTEOPOROTIC FEMALES", Bone and mineral, 27(1), 1994, pp. 13-23

Abstract

To determine the potential adverse effects, if any, of long-term fluoride ingestion in humans, samples were collected from 25 adult femalestaking daily doses of fluoride (mean, 23 mg elemental Fl for the treatment of osteoporosis and from 38 osteoporotic female controls. Patients in the fluoride group had been receiving therapy for approximately 18 months with a mean duration of 4.2 years and had serum fluoride values of at least 10 mu mol/l. Laboratory analyses for fluoride were conducted on plasma, urine and drinking water samples collected from eachpanelist. Blood was also collected for blood chemistry analyses and plasma lymphocytes were examined for the frequency of sister chromatid exchange (SCE). Plasma and urine fluoride levels were significantly different between the two groups, while water fluoride was not. The SCE frequency, a measurement of potential genotoxicity, did not differ between the two groups. Of the blood chemistry parameters measured, albumin, alkaline phosphatase, sodium, chloride, the albumin/globulin (A/G)ratio, indirect bilirubin, lactate dehydrogenase (LDH), and gamma-glutamyl transferase (GGT) were found to be significantly different between the two groups (P less than or equal to 0.05). However, none of themean group values were outside stated normal ranges for any of these parameters. We conclude that the risk of developing adverse systemic effects from the ingestion of fluoride, at dosages and for a duration comparable with that of our panel, is minimal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 05:33:10