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Titolo:
ANTAGONISTIC EFFECTS OF TRIFLUOPERAZINE, IMIPRAMINE, AND CHLORPROMAZINE AGAINST ACETYLCHOLINE-INDUCED CONTRACTIONS IN ISOLATED RAT UTERUS
Autore:
BALAIS SYH; PRADO WA; ALVESDOPRADO W;
Indirizzi:
UNIV MARINGIA,DEPT PHARMACOL BR-87020900 MARINGA PARANA BRAZIL UNIV MARINGIA,DEPT PHARMACOL BR-87020900 MARINGA PARANA BRAZIL FAC MED RIBEIRAO PRETO,DEPT PHARMACOL BR-14049900 SAO PAULO SP BRAZIL
Titolo Testata:
Zhongguo yaoli xuebao
fascicolo: 2, volume: 18, anno: 1997,
pagine: 97 - 100
SICI:
0253-9756(1997)18:2<97:AEOTIA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCARINIC RECEPTORS;
Keywords:
UTERINE CONTRACTION; ACETYLCHOLINE; IMIPRAMINE; PIRENZEPINE; AF-DX 116; 4-DAMP; ATROPINE; CHLORPROMAZINE; TRIFLUOPERAZINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
6
Recensione:
Indirizzi per estratti:
Citazione:
S.Y.H. Balais et al., "ANTAGONISTIC EFFECTS OF TRIFLUOPERAZINE, IMIPRAMINE, AND CHLORPROMAZINE AGAINST ACETYLCHOLINE-INDUCED CONTRACTIONS IN ISOLATED RAT UTERUS", Zhongguo yaoli xuebao, 18(2), 1997, pp. 97-100

Abstract

AIM: To examine the effects and affinity of some phenothizines (trifluoperazine, Tri and chlorpromazine, Chi) and antidepressant (imipramine, Imi) drugs on acetylcholine (ACh)-induced uterine contraction. METHODS: Isotonic contractions of rat uterine strips were recorded. ACh was administrated to induce maximal contraction before exchange of nutrient solution. ACh was added 5 min after the testing drugs. The nutrient solution was exchanged 4 times after each agonist (ACh or other agents) to produce maximal contraction. RESULTS: Atropine (Atr, 0.029 - 2.9 mu mol . L(-1)), 4-DAMP (3.6 - 360 nmol . L(-1)), pirenzepine (Pir, 0.23 - 23.5 mu mol . L(-1)), and AF-DX 116 (0.7 - 35.6 mu mol . L(-1))competitively antagonized the muscular uterine contraction induced byACh (0.068-36068 mu mol . L(-1)). The Schild plot was linear (r = 1.00). The pK(B) and slopes values (95 % confidence limits) were 9.28 +/-0.12 and 1.00 +/- 0.10 to Atr, 9.06 +/- 0.10 and 1.10 +/- 0.08 to 4-DAMP, 7.03 +/- 0.15 and 0.99 +/- 0.12 to Pir, and 5.60 +/- 0.08 and 1.00 +/- 0.19 to AF-DX 116. Tri 0.01 - 2 mu mol . L(-1) (pK(B) = 8.39 +/-0.04) and Imi 94 - 940 nmol . L(-1) (pK(B) = 7.21 +/- 0.10) produced also a competitive antagonism of the muscular uterine contraction induced by ACh (r = 1.00), but the slope was only 0.60 +/- 0.03 to Tri or 0.83 +/- 0.16 to Imi. Chl 2.8 - 5.6 mu mol . L(-1) produced a weak antagonism on amplitude of muscular contraction induced by the cholinomimetic. CONCLUSION: The muscarinic receptors on uterus behaved as M(3) subtype. Tri and Imi, but: not Chl, were competitive antagonist of muscarinic receptors of uterus. Imi behaved a simple competitive antagonist at a single site on myometrium, but Tri was not a simple competitiveagent at a single site.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 18:44:29