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Titolo:
NITRIC-OXIDE AND OPIOID TOLERANCE
Autore:
BABEY AM; KOLESNIKOV Y; CHENG J; INTURRISI CE; TRIFILLETTI RR; PASTERNAK GW;
Indirizzi:
MEM SLOAN KETTERING CANC CTR,DEPT NEUROL,COTZIAS LAB NEUROONCOL,1275 YORK AVE NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,DEPT NEUROL,COTZIAS LAB NEUROONCOL NEW YORK NY 10021 CORNELL UNIV,COLL MED,DEPT NEUROL NEW YORK NY 10021 CORNELL UNIV,COLL MED,DEPT NEUROSCI NEW YORK NY 10021 CORNELL UNIV,COLL MED,DEPT PHARMACOL NEW YORK NY 10021
Titolo Testata:
Neuropharmacology
fascicolo: 11, volume: 33, anno: 1994,
pagine: 1463 - 1470
SICI:
0028-3908(1994)33:11<1463:NAOT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MORPHINE-TOLERANCE; NALOXONE BENZOYLHYDRAZONE; RECEPTOR ANTAGONIST; ADENYLATE-CYCLASE; MESSENGER-RNA; INHIBITION; SYNTHASE; RAT; ANTINOCICEPTION; MICE;
Keywords:
MORPHINE; MU RECEPTOR; KAPPA RECEPTOR; NITRO-ARGININE; ARGININE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Babey et al., "NITRIC-OXIDE AND OPIOID TOLERANCE", Neuropharmacology, 33(11), 1994, pp. 1463-1470

Abstract

Under conditions in which N-G-nitro-L-arginine (NOArg) treatment prevents morphine tolerance, NOArg induces a slow progressive inhibition of nitric oxide synthase (NOS), starting at approx. 20% after a single treatment and increasing to approx. 65% after 10 days. Studies designed to examine potential changes in NOS levels with chronic morphine administration reveal no change. Total NOS activity in both brainstem andcerebellum homogenates is unchanged, as are levels of NOS mRNA in a variety of brain regions. L-Arginine, the precursor of nitric oxide (NO), accelerates tolerance when coadministered with morphine and when given alone L-arginine decreases morphine's potency. Administration of L-arginine alone for 3-10 days shifts morphine's dose-response curve over 2-fold to the right while D-arginine is without effect, as is dailyadministration of L-arginine along with the NOS inhibitor NOArg. Thus, chronic L-arginine induces ''tolerance'' in opioid naive mice through NOS. Together, our data indicate an important role for NO in the modulation of opioid analgesia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 06:22:39