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Titolo:
EFFECT OF ACUTE LUNG INJURY AND COEXISTING DISORDERS ON PLASMA-CONCENTRATIONS OF ATRIAL-NATRIURETIC-PEPTIDE
Autore:
TANABE M; UEDA M; ENDO M; KITAJIMA M;
Indirizzi:
KEIO UNIV,SCH MED,DEPT SURG,SHINJUKU KU,35-SHINANOMACHI TOKYO 160 JAPAN KEIO UNIV,SCH MED,DEPT SURG,SHINJUKU KU TOKYO 160 JAPAN
Titolo Testata:
Critical care medicine
fascicolo: 11, volume: 22, anno: 1994,
pagine: 1762 - 1768
SICI:
0090-3493(1994)22:11<1762:EOALIA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; PULMONARY-HYPERTENSION; PHYSIOLOGICAL-ROLE; ANF RELEASE; POLYPEPTIDE; FAILURE; HYPOXIA; BLOOD; SEPSIS; HEART;
Keywords:
RESPIRATORY FAILURE, ACUTE; ADULT RESPIRATORY DISTRESS SYNDROME; SEPSIS; ASPIRATION PNEUMONIA; BURNS; SURGERY; CRITICAL ILLNESS; ATRIAL NATRIURETIC PEPTIDE; SEVERITY OF ILLNESS INDEX; REGRESSION ANALYSIS; LUNG INJURY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M. Tanabe et al., "EFFECT OF ACUTE LUNG INJURY AND COEXISTING DISORDERS ON PLASMA-CONCENTRATIONS OF ATRIAL-NATRIURETIC-PEPTIDE", Critical care medicine, 22(11), 1994, pp. 1762-1768

Abstract

Objective: To clarify how plasma atrial natriuretic peptide concentrations vary with the severity of acute lung injury. The influence of coexisting diseases which trigger acute lung injury was also examined. Design: Prospective study. Setting: Intensive care unit of a universityhospital. Patients: Fifty patients who had standard risk factors for acute lung injury including sepsis syndrome, major surgery, prolonged hypotension, aspiration of gastric contents, and burns. Twenty-five ofthese patients had acute lung injury (group 3) caused by these disorders; the remaining 25 patients had risk factors only (group 2). Ten age-matched normal volunteers were selected as controls (group 1). Intervention: None. Measurements and Main Results: Plasma atrial natriuretic peptide concentration was measured in these patients and compared with the severity of acute lung injury. In group 3, a significant increase in the mean plasma atrial natriuretic peptide concentration was observed (188 +/- 78 pg/mL, p < .01) compared with group 2 (54 +/- 28 pg/mL) and the age-matched control group (30 +/- 8 pg/mL). This increase was related to the onset of acute lung injury and returned to control concentrations after recovery. Plasma atrial natriuretic peptide concentrations in group 3 correlated highly with a lung injury score representing the severity of acute lung injury (r(2) = .45, P < .01), but did not correlate with other cardiopulmonary variables. Conclusion: The results suggest that severity of lung injury, but not other predisposing disorders, may be the key factor leading to the increase in plasma atrial natriuretic peptide concentrations observed in these patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:41:22