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Titolo:
POLYGLANDULAR AUTOIMMUNE SYNDROME - INCID ENCE, FORMS AND CLINICAL-SIGNIFICANCE
Autore:
WEYERMANN D; SPINAS G; ROTH S; GUGLIELMETTI M; VIOLLIER E; STAUB JJ;
Indirizzi:
UNIV BASEL KLINIKEN,KANTONSSPITAL,DEPT INNERE MED,ENDOKRINOL & STOFFWECHSEL ABT CH-4031 BASEL SWITZERLAND UNIV BASEL KLINIKEN,KANTONSSPITAL,DEPT INNERE MED,ENDOKRINOL & STOFFWECHSEL ABT CH-4031 BASEL SWITZERLAND UNIV SPITAL ZURICH,DEPT INNERE MED ZURICH SWITZERLAND INST DR VIOLLIER BASEL SWITZERLAND
Titolo Testata:
Schweizerische medizinische Wochenschrift
fascicolo: 44, volume: 124, anno: 1994,
pagine: 1971 - 1975
SICI:
0036-7672(1994)124:44<1971:PAS-IE>2.0.ZU;2-R
Fonte:
ISI
Lingua:
GER
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
6
Recensione:
Indirizzi per estratti:
Citazione:
D. Weyermann et al., "POLYGLANDULAR AUTOIMMUNE SYNDROME - INCID ENCE, FORMS AND CLINICAL-SIGNIFICANCE", Schweizerische medizinische Wochenschrift, 124(44), 1994, pp. 1971-1975

Abstract

In a retrospective case finding study we collected data from patientswith polyglandular autoimmune syndrome type II (PGAS Type II) who hadbeen treated in our endocrine outpatient clinic between 1975 and 1989. 31 adult patients (25 females and 6 males) fulfilled the criteria for PGAS Type II (association of autoimmune endocrine disease with at least one other - usually endocrine - autoimmune disease or autoantibodies against another organ). Among these patients, 18 had hypothyroidismdue to autoimmune thyroiditis, 8 were hyperthyroid (Graves' disease),and 4 had silent autoimmune thyroiditis (without thyroid dysfunction). Insulin dependent (type I) diabetes mellitus (IDDM) was seen in 11, Addison's disease in 7, primary hypogonadism in 5, vitiligo in 6 and pernicious anemia in 5 cases. The presence of antiparietal cell antibodies was demonstrated in 21 of 30 investigated patients. These patientsalso showed other evidence of autoimmune gastritis, such as increasedgastrin (in 10 out of 13), diminished vitamin B-12 levels (6 out of 13), atrophic gastritis (9 out of 9), pernicious anemia (6 out of 30) and funicular myelosis (2 out of 30). Conclusion: The most common endocrine diseases in our patient group were autoimmune thyroid diseases (97%) followed by IDDM (35%) and Addison's disease (23%). A high percentage (70%) of our subjects had elevated titers of antiparietal cell antibodies. Polyglandular autoimmune syndrome must be suspected in all patients with autoimmune endocrine disease, especially in the presence of relatives suffering from PGAS. Patients at risk should be screened regularly by measuring thyrotropin (ultrasensitive assay), fasting blood glucose levels, and by checking red blood count and antiparietal cell antibodies. In the presence of two combined endocrinopathies and/or of clinical signs suggestive of Addison's disease a rapid ACTH stimulation test is mandatory.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 02:42:36