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Titolo:
SIMULATIONS OF INTRINSICALLY BURSTING NEOCORTICAL PYRAMIDAL NEURONS
Autore:
RHODES PA; GRAY CM;
Indirizzi:
UNIV CALIF DAVIS,CTR NEUROSCI DAVIS CA 95616 SALK INST BIOL STUDIES LA JOLLA CA 92037
Titolo Testata:
Neural computation
fascicolo: 6, volume: 6, anno: 1994,
pagine: 1086 - 1110
SICI:
0899-7667(1994)6:6<1086:SOIBNP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORIMOTOR CORTEX INVITRO; VISUAL-CORTEX; DENDRITIC MORPHOLOGY; HIPPOCAMPAL-NEURONS; MEMBRANE-PROPERTIES; IONIC CONDUCTANCES; CALCIUM CURRENTS; SENSORY NEURONS; FIRING NEURONS; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
CompuMath Citation Index
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
P.A. Rhodes e C.M. Gray, "SIMULATIONS OF INTRINSICALLY BURSTING NEOCORTICAL PYRAMIDAL NEURONS", Neural computation, 6(6), 1994, pp. 1086-1110

Abstract

Neocortical layer 5 intrinsically bursting (IB) pyramidal neurons were simulated using compartment model methods. Morphological data as well as target neurophysiological responses were taken from a series of published studies on the same set of rat visual cortex pyramidal neurons (Mason, A. and Larkman, A. J., 1990. J. Neurosci. 9, 1440-1447; Larkman, A. J. 1991. J. Corny. Neurol. 306, 307-319). A dendritic distribution of ion channels was found that reproduced the range of in vitro responses of layer 5 IB pyramidal neurons, including the transition from repetitive bursting to the burst/tonic spiking mode seen in these neurons as input magnitude increases. In light of available data, the simulation results suggest that in these neurons bursts are driven by aninward flow of current during a high threshold Ca2+ spike extending throughout both the basal and apical dendritic branches.

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Documento generato il 07/07/20 alle ore 12:19:38