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Titolo:
INFERTILITY SECONDARY TO VALPROATE
Autore:
CURTIS VL; OELBERG DG; WILLMORE LJ;
Indirizzi:
UNIV TEXAS,HLTH SCI CTR,DEPT NEUROL,SUITE 7044,6431 FANNIN HOUSTON TX77030 EASTERN VIRGINIA MED SCH,CTR PEDIAT RES,DIV NEONATAL PERINATAL MED NORFOLK VA 23501
Titolo Testata:
Journal of epilepsy
fascicolo: 4, volume: 7, anno: 1994,
pagine: 259 - 261
SICI:
0896-6974(1994)7:4<259:ISTV>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPRODUCTIVE ENDOCRINE DISORDERS; TEMPORAL-LOBE ORIGIN; EPILEPTIC PATIENTS; PARTIAL SEIZURES; DRUGS;
Keywords:
INFERTILITY; VALPROATE; SPERMATOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
V.L. Curtis et al., "INFERTILITY SECONDARY TO VALPROATE", Journal of epilepsy, 7(4), 1994, pp. 259-261

Abstract

Valproic acid (VPA) is generally thought to be more benign in terms of fertility effects in patients with epilepsy than carbamazepine (CBZ)or phenytoin (PHT) due to its lack of liver-enzyme-inducing properties. We report a patient treated with VPA for partial seizures, previously fertile on CBZ. When conception failed while taking VPA, semen analysis revealed a decreased number of sperm, reduced motility, and altered morphology. Endocrinologic studies and evaluation of the patient's wife were all normal. Successful pregnancy was achieved and abnormal sperm indices reverted to normal when VPA was discontinued and CBZ reinstituted. It is probable that a direct gonadal or sperm membrane effect of VPA is the responsible mechanism for this rare phenomenon.

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Documento generato il 04/07/20 alle ore 18:17:37