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Titolo:
CEREBRAL EFFECTS OF NITROUS-OXIDE DURING ISOFLURANE-INDUCED HYPOTENSION IN THE PIG
Autore:
TSAI YC; LIN SS; LEE KC; CHANG CL;
Indirizzi:
NATL CHENG KUNG UNIV,COLL MED,DEPT ANAESTHESIOL,138 SHENG LI RD TAINAN 70428 TAIWAN
Titolo Testata:
British Journal of Anaesthesia
fascicolo: 5, volume: 73, anno: 1994,
pagine: 667 - 672
SICI:
0007-0912(1994)73:5<667:CEONDI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW VELOCITY; LASER-DOPPLER FLOWMETRY; INTRA-CRANICAL PRESSURE; INTRACRANIAL-PRESSURE; BRAIN MICROCIRCULATION; ANEURYSM SURGERY; DOGS; ANESTHESIA; VOLUME; HALOTHANE;
Keywords:
ANESTHETIC TECHNIQUES, HYPOTENSIVE; ANESTHETICS GASES, NITROUS OXIDE; ANESTHETICS VOLATILE, ISOFLURANE; BRAIN, BLOOD FLOW; BRAIN, INTRACRANIAL PRESSURE; PIG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
Y.C. Tsai et al., "CEREBRAL EFFECTS OF NITROUS-OXIDE DURING ISOFLURANE-INDUCED HYPOTENSION IN THE PIG", British Journal of Anaesthesia, 73(5), 1994, pp. 667-672

Abstract

We have studied the effects of nitrous oxide on cerebral blood flow (CBF), cerebral blood flow velocity (CBFV) and intracranial pressure (ICP) during isoflurane-induced hypotension in 10 pig's. CBF was measured using laser Doppler flowmetry, CBFV in the right middle cerebral artery was calculated using Doppler ultrasound and ICP was measured usingan extradural ICP monitor. Each animal was studied under four conditions, examined sequentially: (i) mean intra-arterial pressure (MAP) 85 mm Hg, maintained with isoflurane, (ii) MAP 50-55 mm Hg, induced by isoflurane only, (iii) MAP 85 mm Hg, maintained with isoflurane and 50% nitrous oxide, and (iv) MAP 50-55 mm Hg, induced by isoflurane and 50%nitrous oxide. No significant differences were noted between conditions with respect to ICP. There was a significant difference in CBF during condition (ii) compared with (i) (mean 75(SD 21) vs 100(0)%) and during condition (iv) compared with (iii) (90(26) vs 109(13)%). Animals under condition (iv) exhibited a 20% reduction in CBFV compared with those under condition (iii) (57 vs 69 cm s(-1)). For animals under normotensive conditions, addition of nitrous oxide to isoflurane resulted in a 16% increase in CBFV (69 vs 60 cm s(-1)). Comparing isoflurane-induced hypotension ((ii) vs (iv)), there was no statistical difference in either CBF or CBFV on addition of 50% nitrous oxide. The correlation between changes in CBF and CBFV was not significant. We conclude that the use of nitrous oxide during isoflurane-induced hypotension has no significant effect on CBF, CBFV or ICP compared with the use of isoflurane alone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:23:51