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Titolo:
BACTERIAL TRANSLOCATION IN CIRRHOTIC RATS - ITS ROLE IN THE DEVELOPMENT OF SPONTANEOUS BACTERIAL PERITONITIS
Autore:
LLOVET JM; BARTOLI R; PLANAS R; CABRE E; JIMENEZ M; URBAN A; OJANGUREN I; ARNAL J; GASSULL MA;
Indirizzi:
HOSP UNIV GERMANS TRIAS & PUJOL,DEPT GASTROENTEROL,CARRETERA CANYET S-N E-08916 BADALONA SPAIN HOSP UNIV GERMANS TRIAS & PUJOL,DEPT GASTROENTEROL E-08916 BADALONA SPAIN HOSP UNIV GERMANS TRIAS & PUJOL,DEPT MICROBIOL E-08916 BADALONA SPAIN HOSP UNIV GERMANS TRIAS & PUJOL,DEPT PATHOL E-08916 BADALONA SPAIN
Titolo Testata:
Gut
fascicolo: 11, volume: 35, anno: 1994,
pagine: 1648 - 1652
SICI:
0017-5749(1994)35:11<1648:BTICR->2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESENTERIC LYMPH-NODES; INDIGENOUS BACTERIA; ASCITIC FLUID; INTESTINAL BACTERIA; HEMORRHAGIC-SHOCK; OPSONIC ACTIVITY; MODEL; GUT; PATHOGENESIS; RECURRENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Llovet et al., "BACTERIAL TRANSLOCATION IN CIRRHOTIC RATS - ITS ROLE IN THE DEVELOPMENT OF SPONTANEOUS BACTERIAL PERITONITIS", Gut, 35(11), 1994, pp. 1648-1652

Abstract

Bacterial translocation occurs in ascitic cirrhotic rats, but its association with ascites infection is unknown. The aim of this study was to assess the relation between bacterial translocation and ascites infection in cirrhotic rats. Male Sprague-Dawley rats were induced to cirrhosis with intragastric CCl4. Ascitic fluid, portal and peripheral blood, mesenteric lymph nodes, liver and spleen samples were cultured before death in those cirrhotic rats with less (group A) or more (group B) than 250 polymorphonuclear neutrophils/mm(3) in ascitic fluid, as well as in healthy control rats. Histological examination of jejunum, ileum, and caecum was also performed. Bacterial translocation occurred in 45% of ascitic rats (without differences between groups A and B), but in 0% controls (p=0.01). Bacterial translocation was associated with positive ascitic fluid culture in 60% of the cases. In all of them the same bacterial species was isolated in both mesenteric lymph node and ascitic fluid. Submucosal caecal oedema (100%), heal lymphangiectasia (41%), and caecal inflammatory infiltrate (41%) occurred in asciticrats, the last being associated with ascitic fluid positive culture (p=0.04). These results suggests that bacterial translocation occurs frequently in ascitic cirrhotic rats, and may play a permissive, but notunique, part in a number of ascites infections. Whether histological changes seen in cirrhotic ascitic rats favour bacterial translocation remains to be elucidated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:12:56