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Titolo:
GROWTH FACTOR-MEDIATED TERMINAL DIFFERENTIATION OF CHRONIC MYELOID-LEUKEMIA
Autore:
BEDI A; GRIFFIN CA; BARBER JP; VALA MS; HAWKINS AL; SHARKIS SJ; ZEHNBAUER BA; JONES RJ;
Indirizzi:
JOHNS HOPKINS UNIV,CTR ONCOL,ROOM 2-127,600 N WOLFE ST BALTIMORE MD 21287 JOHNS HOPKINS UNIV,CTR ONCOL BALTIMORE MD 21287
Titolo Testata:
Cancer research
fascicolo: 21, volume: 54, anno: 1994,
pagine: 5535 - 5538
SICI:
0008-5472(1994)54:21<5535:GFTDOC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMATOPOIETIC PROGENITOR CELLS; CHRONIC MYELOGENOUS LEUKEMIA; EXPRESSION; APOPTOSIS; GENE; INHIBITION; MACROPHAGE; CULTURE; AGENTS; MARROW;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
A. Bedi et al., "GROWTH FACTOR-MEDIATED TERMINAL DIFFERENTIATION OF CHRONIC MYELOID-LEUKEMIA", Cancer research, 54(21), 1994, pp. 5535-5538

Abstract

Expression of the BCR-ABL chimeric gene in chronic myeloid leukemia results in the inhibition of apoptosis, a genetically programmed process of autonomous cell death. BCR-ABL and other genetic factors that suppress apoptosis confer cross-resistance to cytotoxic agents with diverse mechanisms of action. Eradication of the chronic myeloid leukemia clone requires strategies that circumvent this inherent resistance to cytotoxic therapy. We have determined that BCR-ABL expression augments the sensitivity of hematopoietic cells to growth factor-mediated signals of differentiation; hematopoietic growth factors induce the selective terminal differentiation of chronic myeloid leukemia progenitors atconcentrations that allow optimal growth of normal progenitors. Hematopoietic growth factors may be an effective strategy for the elimination of cytotoxic therapy-resistant Leukemic cells by inducing their terminal differentiation while allowing concomitant expansion of coexistent normal hematopoietic progenitors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:03:01