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Titolo:
ANTINOCICEPTIVE AND ANTIPYRETIC EFFECTS OF ALKALOIDS EXTRACTED FROM THE STEM BARK OF HUNTERIA-ZEYLANICA
Autore:
REANMONGKOL W; MATSUMOTO K; WATANABE H; SUBHADHIRASAKUL S; SAKAI SI;
Indirizzi:
TOYAMA MED & PHARMACEUT UNIV,WAKAN YAKU RES INST,DIV PHARMACOL,2630 SUGITANI TOYAMA 93001 JAPAN TOYAMA MED & PHARMACEUT UNIV,WAKAN YAKU RES INST,DIV PHARMACOL TOYAMA93001 JAPAN PRINCE SONGKLA UNIV,FAC PHARMACEUT SCI,DEPT PHARMACEUT BOT & PHARMACOGNOSY SONGKHLA 90112 THAILAND CHIBA UNIV,FAC PHARMACEUT SCI,DEPT PHARMACEUT CHEM CHIBA 263 JAPAN
Titolo Testata:
Biological & pharmaceutical bulletin
fascicolo: 10, volume: 17, anno: 1994,
pagine: 1345 - 1350
SICI:
0918-6158(1994)17:10<1345:AAAEOA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
FORMALIN TEST; MICE;
Keywords:
HUNTERIA ZEYLANICA; ANTINOCICEPTIVE ACTIVITY; CAPILLARY PERMEABILITY; ANTIPYRETIC ACTIVITY; ANTIINFLAMMATORY ACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
W. Reanmongkol et al., "ANTINOCICEPTIVE AND ANTIPYRETIC EFFECTS OF ALKALOIDS EXTRACTED FROM THE STEM BARK OF HUNTERIA-ZEYLANICA", Biological & pharmaceutical bulletin, 17(10), 1994, pp. 1345-1350

Abstract

Effects of crude alkaloids extracted from the stem bark of Hunter ia zeylanica GARD. (H. zeylanica) on nociceptive responses, capillary permeability, yeast-induced hyperthermia, pentobarbital-induced sleep, and spontaneous motor activity were investigated. Oral administration of50 mg/kg H. zeylanica alkaloid extract significantly decreased the number of writhings induced by intraperitoneal acetic acid. The extract at 100-200 mg/kg significantly increased nociceptive threshold of the inflamed but not the non-inflamed paw in the Randall-Selitto test. Moreover, in the formalin test, the extract (100 mg/kg) significantly decreased licking activity in the late phase without affecting the activity in the early phase. However, the extract did not produce antinociceptive effect in the hot plate test, while it inhibited increase of vascular permeability induced by acetic acid in the capillary permeability test. Moreover, the extract dose-dependently reduced yeast-induced hyperthermia in rats without affecting normothermia. It did not affect pentobarbital-induced sleep, but significantly increased locomotor activity at 100 mg/kg. These results suggest that H. zeylanica alkaloid extract possesses antinociceptive and antipyretic effects, and that theformer effect may be mediated by its anti-inflammatory action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 07:41:28