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Titolo:
APOPTOTIC CHANGES IN THE THYMUS OF MICE INFECTED WITH MOUSE HEPATITIS-VIRUS, MHV-2
Autore:
LEE SK; YOUN HY; HASEGAWA A; NAKAYAMA H; GOTO N;
Indirizzi:
UNIV TOKYO,FAC AGR,DEPT VET PATHOL,1-1-1 YAYOI,BUNKYO KU TOKYO 113 JAPAN UNIV TOKYO,FAC AGR,DEPT VET INTERNAL MED,BUNKYO KU TOKYO 113 JAPAN
Titolo Testata:
Journal of veterinary medical science
fascicolo: 5, volume: 56, anno: 1994,
pagine: 879 - 882
SICI:
0916-7250(1994)56:5<879:ACITTO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; VIRAL PATHOGENICITY; LYMPHOCYTE-T; ANEMIA;
Keywords:
APOPTOSIS; MHV-2; THYMUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
S.K. Lee et al., "APOPTOTIC CHANGES IN THE THYMUS OF MICE INFECTED WITH MOUSE HEPATITIS-VIRUS, MHV-2", Journal of veterinary medical science, 56(5), 1994, pp. 879-882

Abstract

In mice infected with MHV-2, histopathological changes of the thymus was studied. Extensive cell lysis with pyknotic nuclear debris appeared at 48 hr postinfection, and cortico-medullary border was indistinguishable. Electron microscopy revealed vacuolation and shrinkage of the cytoplasm of lymphoid cells, margination of nuclear chromatin, and fragmentation of nuclei. Virus particles were detectable in the lymphoid and reticular epithelial cells, being immunohistochemically positive for viral antigen. By DNA electrophoresis thymocytes showed DNA fragmentation with a laddering pattern characteristic of apoptosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:35:48