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Titolo:
TUMOR-NECROSIS-FACTOR AND EICOSANOID PRODUCTION FROM MONOCYTES EXPOSED TO HIV IN-VITRO
Autore:
SKOT J; KABRIT P; HANSEN JES; NIELSEN JO; NIELSEN L; LUNDGREN JD;
Indirizzi:
UNIV COPENHAGEN,HVIDOVRE HOSP,DEPT INFECT DIS 144,KETTEGARDS ALLE 30 DK-2650 HVIDOVRE DENMARK STATENS SERUM INST COPENHAGEN DENMARK
Titolo Testata:
APMIS. Acta pathologica, microbiologica et immunologica Scandinavica
fascicolo: 8, volume: 102, anno: 1994,
pagine: 603 - 611
SICI:
0903-4641(1994)102:8<603:TAEPFM>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; FACTOR-ALPHA; GENE-EXPRESSION; INFECTED MACROPHAGES; MONONUCLEAR-CELLS; TYPE-1; LIPOPOLYSACCHARIDE; INTERLEUKIN-1; CYTOKINES; INDUCTION;
Keywords:
LTB4; PGE2; EICOSANOIDS; TNF; MONOCYTES; HIV-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
J. Skot et al., "TUMOR-NECROSIS-FACTOR AND EICOSANOID PRODUCTION FROM MONOCYTES EXPOSED TO HIV IN-VITRO", APMIS. Acta pathologica, microbiologica et immunologica Scandinavica, 102(8), 1994, pp. 603-611

Abstract

We investigated the hypothesis that exposure of monocytes to human immunodeficiency virus (HIV) augments production of proinflammatory mediators. The production of tumour necrosis factor alpha (TNF-alpha) and the eicosanoids PGE(2) and LTB(4) from human monocytes was evaluated after exposure to two strains of HIV (SSI-002 or HIV-1(IIIB)). After 16h incubation with low doses of SSI-002, lipopolysaccharide-stimulatedTNF-alpha production was enhanced 70-85% while PGE(2) production was decreased. Heat-inactivated virus failed to alter the production of these mediators. Higher viral doses tended to decrease TNF-alpha and PGE(2) production concomitantly, but this might be due to toxicity. HIV-1(IIIB) had no effect on either TNF-alpha or PGE(2) production. Calciumionophore-stimulated LTB(4) production was doubled by HIV-1(IIIB) butsignificantly decreased by SSI-002 Three or seven days after exposureto both HIV strains, increased PGE(2) production was found. In conclusion, HIV only modestly altered the production of mediators from monocytes. The effects were strain-specific. In most experiments a second stimulus was required to demonstrate differences.

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Documento generato il 28/11/20 alle ore 09:42:12