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Titolo:
EVIDENCE THAT CA2-ACTIVATED K+ CHANNELS PARTICIPATE IN THE REGULATIONOF PITUITARY PROLACTIN SECRETION()
Autore:
WANG XB; INUKAI T; GREER MA; GREER SE;
Indirizzi:
OREGON HLTH SCI UNIV,DEPT PHYSIOL,DIV ENDOCRINOL PORTLAND OR 97201 OREGON HLTH SCI UNIV,DEPT PHYSIOL,DIV ENDOCRINOL PORTLAND OR 97201 OREGON HLTH SCI UNIV,DEPT MED PORTLAND OR 97201
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 662, anno: 1994,
pagine: 83 - 87
SICI:
0006-8993(1994)662:1-2<83:ETCKCP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROTROPIN-RELEASING-HORMONE; RAT LACTOTROPH CELLS; ACTIVATED POTASSIUM CHANNELS; CHROMAFFIN CELLS; CALCIUM CURRENTS; GH4C1 CELLS; GH3 CELLS; DOPAMINE; TRANSDUCTION; SOMATOSTATIN;
Keywords:
CA2+-ACTIVATED K+ CHANNEL; PROLACTIN SECRETION; PITUITARY CELL; DOPAMINE; NIFEDIPINE; PERIFUSION; CHARYBDOTOXIN; APAMIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
X.B. Wang et al., "EVIDENCE THAT CA2-ACTIVATED K+ CHANNELS PARTICIPATE IN THE REGULATIONOF PITUITARY PROLACTIN SECRETION()", Brain research, 662(1-2), 1994, pp. 83-87

Abstract

We evaluated the role of Ca2+-activated K+ channels in the regulationof prolactin (PRL) secretion with a perifusion system using acutely dispersed rat anterior pituitary cells. Apamin, which blocks Ca2+-activated K+ channels, induced PRL secretion in a dose-dependent fashion between 1 and 300 nM (r = 0.99, P < 0.01). Charybdotoxin, another Ca2+-activated K+ channel-blocker, also induced PRL secretion at 20 nM concentration. These were not non-specific toxic effects, since stimulationof PRL secretion by 10 nM thyrotropin-releasing hormone (TRH) was notdifferent before and after applying the channel-blockers. Both 10 mu M dopamine and 2 mu M nifedipine significantly, but incompletely, depressed PRL secretion induced by 100 nM apamin; 10 mu M dopamine completely blocked PRL secretion induced by 20 nM charybdotoxin. Our data indicate that Ca2+-activated K+ channels may play an important role in the regulation of PRL secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:13:46