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Titolo:
ESTIMATION OF TISSUE HYPOTHYROIDISM BY A NEW CLINICAL SCORE - EVALUATION OF PATIENTS WITH VARIOUS GRADES OF HYPOTHYROIDISM AND CONTROLS
Autore:
ZULEWSKI H; MULLER B; EXER P; MISEREZ AR; STAUB JJ;
Indirizzi:
UNIV BASEL HOSP,DEPT MED,DIV ENDOCRINOL CH-4031 BASEL SWITZERLAND UNIV BASEL HOSP,DEPT MED,DIV ENDOCRINOL CH-4031 BASEL SWITZERLAND
Titolo Testata:
The Journal of clinical endocrinology and metabolism
fascicolo: 3, volume: 82, anno: 1997,
pagine: 771 - 776
SICI:
0021-972X(1997)82:3<771:EOTHBA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBCLINICAL HYPOTHYROIDISM; DOUBLE-BLIND; HORMONE; THYROTROPIN; WOMEN; TSH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
H. Zulewski et al., "ESTIMATION OF TISSUE HYPOTHYROIDISM BY A NEW CLINICAL SCORE - EVALUATION OF PATIENTS WITH VARIOUS GRADES OF HYPOTHYROIDISM AND CONTROLS", The Journal of clinical endocrinology and metabolism, 82(3), 1997, pp. 771-776

Abstract

The classical signs and symptoms of hypothyroidism were reevaluated in the light of the modern laboratory tests for thyroid function. We analyzed 332 female subjects: 50 overt hypothyroid patients, 93 with subclinical hypothyroidism (SCH), 67 hypothyroid patients treated with T-4, and 189 euthyroid subjects. The clinical score was defined as the sum of the 2 best discriminating signs and symptoms. Beside TSH and thyroid hormones, we measured parameters known to reflect tissue manifestations of hypothyroidism, such as ankle reflex relaxation time and total cholesterol. Classical signs of hypothyroidism were present only inpatients with severe overt hypothyroidism with low T-3, but were rareor absent in patients with normal T-3, but low free T-4, or in patients with SCH (normal thyroid hormones but elevated basal TSH; mean scores, 7.8 +/- 2.7 vs. 4.4 +/- 2.2 vs. 3.4 +/- 2.0; P < 0.001). Assessment of euthyroid subjects and T-4-treated patients revealed very similarresults (mean score, 1.6 +/- 1.6 us. 2.1 +/- 1.5). In overt hypothyroid patients, the new score showed an excellent correlation with ankle reflex relaxation time and total cholesterol (r = 0.76 and r = 0.60; P< 0.0001), but no correlation with TSH (r = 0.01). The correlation with free T-4 was r = -0.52 (P < 0.0004); and that with T-3 was r = -0.56 (P < 0.0001). In SCH, the best correlation was found between the newscore and free T-4 (r = -0.41; P < 0.0001) and TSH (r = 0.35; P < 0.0005). Evaluation of symptoms and signs of hypothyroidism with the new score in addition to thyroid function testing is very useful for the individual assessment of thyroid failure and the monitoring of treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 02:59:29