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Titolo:
COMPARATIVE-ANALYSIS OF PAX-6 SEQUENCE AND EXPRESSION IN THE EYE DEVELOPMENT OF THE BLIND CAVE FISH ASTYANAX-FASCIATUS AND ITS EPIGEAN CONSPECIFIC
Autore:
BEHRENS M; LANGECKER TG; WILKENS H; SCHMALE H;
Indirizzi:
UNIV KRANKENHAUS EPPENDORF,INST ZELLBIOCHEM & KLIN NEUROBIOL,MARTINISTR 52 D-20246 HAMBURG GERMANY UNIV KRANKENHAUS EPPENDORF,INST ZELLBIOCHEM & KLIN NEUROBIOL D-20246 HAMBURG GERMANY UNIV HAMBURG,ZOOL INST & MUSEUM D-2000 HAMBURG GERMANY
Titolo Testata:
Molecular biology and evolution
fascicolo: 3, volume: 14, anno: 1997,
pagine: 299 - 308
SICI:
0737-4038(1997)14:3<299:COPSAE>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOMEOBOX-CONTAINING GENE; OPSIN GENE; MUTATION; CHARACIDAE; EVOLUTION; ANIRIDIA; MOUSE; LENS; CONSERVATION; DROSOPHILA;
Keywords:
ASTYANAX FASCIATUS; PAX-6; REGRESSIVE EVOLUTION; CAVE FISH; EYE DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M. Behrens et al., "COMPARATIVE-ANALYSIS OF PAX-6 SEQUENCE AND EXPRESSION IN THE EYE DEVELOPMENT OF THE BLIND CAVE FISH ASTYANAX-FASCIATUS AND ITS EPIGEAN CONSPECIFIC", Molecular biology and evolution, 14(3), 1997, pp. 299-308

Abstract

The Pax-6 gene encodes a transcription factor essential for eye development in a wide range of animal phyla. In order to elucidate a possible role of Pax-6 in the eye regression of a blind cave form of the freshwater fish Astyanax fasciatus (Characidae, Teleostei) we investigated the expression of Pax-6 in eyes and brains of different larval stages by in situ hybridization. Pattern, strength, and time course of Pax-6 expression were not altered in the tissues of the cave form when compared to the epigean form. Pax-6 was even expressed in the highly degenerated eyes of late larval stages of the cave form. Comparative sequence analysis of Pax-6 cDNA clones of both forms of Astyanax fasciatus showed the complete integrity of cave fish Pax-6 mRNA. These results suggest that Pax-6 is not involved in the evolutionary process of eye degeneration in this model system of cave-living fishes. Comparison of the Astyanax Pax-6 cDNA with the other available fish Pax-6 sequence from zebrafish revealed putative fish-specific regions of homology. A stretch of 19 N-terminal amino acids is nearly identical on the nucleotide and amino acid levels in both fish species but not present in all other known Pax-6 sequences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 05:28:29