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Titolo:
EMPIRICAL THRESHOLD VALUES FOR QUANTITATIVE TRAIT MAPPING
Autore:
CHURCHILL GA; DOERGE RW;
Indirizzi:
CORNELL UNIV,BIOMETR UNIT ITHACA NY 14853
Titolo Testata:
Genetics
fascicolo: 3, volume: 138, anno: 1994,
pagine: 963 - 971
SICI:
0016-6731(1994)138:3<963:ETVFQT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAXIMUM-LIKELIHOOD METHODS; LINKAGE MAPS; MENDELIAN FACTORS; GENETIC-MARKERS; LINE CROSSES; LOCI; AID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
G.A. Churchill e R.W. Doerge, "EMPIRICAL THRESHOLD VALUES FOR QUANTITATIVE TRAIT MAPPING", Genetics, 138(3), 1994, pp. 963-971

Abstract

The detection of genes that control quantitative characters is a problem of great interest to the genetic mapping community. Methods for locating these quantitative trait loci (QTL) relative to maps of geneticmarkers are now widely used. This paper addresses an issue common to all QTL mapping methods, that of determining an appropriate threshold value for declaring significant QTL effects. An empirical method is described, based on the concept of a permutation test, for estimating threshold values that are tailored to the experimental data at hand. Themethod is demonstrated using two real data sets derived from F-2 and recombinant inbred plant populations. An example using simulated data from a backcross design illustrates the effect of marker density on threshold values.

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Documento generato il 05/07/20 alle ore 22:22:19