Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECT OF D-ALA-D-BETA-NAL-ALA-TRP-D-PHE-LYS-NH2 (KP-102) ON GH SECRETION IN URETHANE-ANESTHETIZED RATS
Autore:
SAWADA H; SUGIHARA H; ONOSE H; MINAMI S; SHIBASAKI T; WAKABAYASHI I;
Indirizzi:
NIPPON MED COLL,DEPT MED,DIV ENDOCRINOL,BUNKYO KU,SENDAGI 1-1-5 TOKYO113 JAPAN NIPPON MED COLL,DEPT MED,DIV ENDOCRINOL,BUNKYO KU TOKYO 113 JAPAN TOKYO WOMENS MED COLL,DEPT MED,SHINJUKU KU TOKYO 162 JAPAN
Titolo Testata:
Regulatory peptides
fascicolo: 3, volume: 53, anno: 1994,
pagine: 195 - 201
SICI:
0167-0115(1994)53:3<195:EOD(OG>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-RELEASING PEPTIDE; GROWTH-HORMONE; NORMAL MEN; (GH)-RELEASING PEPTIDE; SYNTHETIC HEXAPEPTIDE; FACTOR GRF; SOMATOSTATIN RELEASE; CONTINUOUS INFUSION; PITUITARY; HIS-D-TRP-ALA-TRP-D-PHE-LYS-NH2;
Keywords:
GROWTH HORMONE-RELEASING PEPTIDE; GROWTH HORMONE-RELEASING FACTOR; SOMATOSTATIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
H. Sawada et al., "EFFECT OF D-ALA-D-BETA-NAL-ALA-TRP-D-PHE-LYS-NH2 (KP-102) ON GH SECRETION IN URETHANE-ANESTHETIZED RATS", Regulatory peptides, 53(3), 1994, pp. 195-201

Abstract

The effect of a newly developed growth hormone (GH)-releasing hexapeptide (KP-102) on GH secretion was studied in urethan-anesthetized adult male rats. Although KP-102 alone exerted a small influence on GH secretion, it produced a large plasma GH response in the presence of exogenous GH-releasing factor (GRF). During the continuous infusion of GRF, the somatotropes became refractory to a large bolus dose of GRF, butKP-102 induced a marked increase of plasma GH. The GH response to KP-102 alone or KP-102 with GRF was significantly augmented when antiserum to somatostatin (ASS) was previously administered. Although KP-102 and GRF acted synergistically on GH secretion in control animals, they acted additively in ASS-administered rats. The KP-102 effect on plasmaGH was significantly at tenuated in control animals and AS S-administered rats by prior i.v. injection of antiserum to GRF. Taken together,KP-102 stimulates GH secretion dependent on GRF and appears to act synergistically with GRF by antagonizing the SS effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 01:56:03