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Titolo:
FRONTAL-SUBCORTICAL CIRCUITS AND NEUROPSYCHIATRIC DISORDERS
Autore:
MEGA MS; CUMMINGS JL;
Indirizzi:
W LOS ANGELES VAMC,NEUROBEHAV UNIT,116AF,BLDG 256B,11301 WILSHIRE BLVD LOS ANGELES CA 90073 UCLA,SCH MED,DEPT NEUROL & PSYCHIAT LOS ANGELES CA 00000 UCLA,SCH MED,DEPT BIOBEHAV SCI LOS ANGELES CA 00000 W LOS ANGELES VET AFFAIRS MED CTR,BEHAV NEUROSCI SECT LOS ANGELES CA 00000
Titolo Testata:
The Journal of neuropsychiatry and clinical neurosciences
fascicolo: 4, volume: 6, anno: 1994,
pagine: 358 - 370
SICI:
0895-0172(1994)6:4<358:FCAND>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; BASAL GANGLIA; RHESUS-MONKEY; PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; SQUIRREL-MONKEY; CAUDATE-NUCLEUS; NIGROSTRIATAL PROJECTIONS; EFFERENT PROJECTIONS; MEDIODORSAL NUCLEUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Mega e J.L. Cummings, "FRONTAL-SUBCORTICAL CIRCUITS AND NEUROPSYCHIATRIC DISORDERS", The Journal of neuropsychiatry and clinical neurosciences, 6(4), 1994, pp. 358-370

Abstract

Five parallel anatomic circuits link regions of the frontal cortex tothe striatum, globus pallidus/substantia nigra, and thalamus. The circuits originate in the supplmentary motor area, frontal eye fields, dorsolateral prefrontal region, lateral orbitofrontal area, and anteriorcingulate cortex. Open loop structures that provide input to or receive output from specific circuits share functions, cytoarchitectural features, and phylogenetic histories with the relevant circuits. The circuits mediate motor and oculomotor function as well as executive functions, socially responsive behavior, and motivation. Neuropsychiatric disorders of frontal-subcortical circuits include impaired executive function, disinhibition, and apathy; indicative mood disorders include depression, mania, and lability. Transmitters, modulators, receptor subtypes, and second messengers within the circuits provide a chemoarchitecture that can inform pharmacotherapy.

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Documento generato il 14/07/20 alle ore 19:32:04