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Titolo:
SUSTAINED ATTENTION IN ADULT PHENYLKETONURIA - THE INFLUENCE OF THE CONCURRENT PHENYLALANINE-BLOOD-LEVEL
Autore:
SCHMIDT E; RUPP A; BURGARD P; PIETZ J; WEGLAGE J; DESONNEVILLE L;
Indirizzi:
UNIV HEIDELBERG,KINDERKLIN,PKU VERBUNDSTUDIE,NEUENHEIMER FELD 150 D-69120 HEIDELBERG GERMANY UNIV HOSP HEIDELBERG,DEPT PEDIAT HEIDELBERG GERMANY UNIV HOSP MUNSTER,DEPT PEDIAT MUNSTER GERMANY FREE UNIV AMSTERDAM HOSP,DEPT PEDIAT NEUROL AMSTERDAM NETHERLANDS
Titolo Testata:
Neuropsychology, development, and cognition. Section A, Journal of clinical and experimental neuropsychology
fascicolo: 5, volume: 16, anno: 1994,
pagine: 681 - 688
SICI:
1380-3395(1994)16:5<681:SAIAP->2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
TREATED PHENYLKETONURIA; PERFORMANCE; BEHAVIOR; CHILDREN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social Sciences Citation Index
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
E. Schmidt et al., "SUSTAINED ATTENTION IN ADULT PHENYLKETONURIA - THE INFLUENCE OF THE CONCURRENT PHENYLALANINE-BLOOD-LEVEL", Neuropsychology, development, and cognition. Section A, Journal of clinical and experimental neuropsychology, 16(5), 1994, pp. 681-688

Abstract

The effect of concurrent phenylalanine levels (Phe-level) on sustained attention was tested in a group of 19 early treated adult PKU patients. Mean age was 20.5 years; WAIS IQs were in the normal range (M = 109.3). Phe-levels were manipulated in a high-low-high design by reintroduction of a strict phenylalanine-reduced diet for 4 to 5 weeks between test time 1 and 2 and returning to usual diet between test time 2 and 3. A control group of 20 healthy subjects, mean age 20.7 years was tested twice. Results of a sustained attention task are presented. In adult PKU patients with high concurrent Phe-Ievels, sustained attentionis significantly impaired and reaction times are prolonged. In the low Phe-level condition, performance improved significantly. Nevertheless, the PKU group did not reach the level of performance of the controlgroup. Results are not influenced by IQ and suggest a sustained attention deficit in adult PKU patients that varies according to the concurrent Phe-level. The partial reversibility of the deficits provides support for the hypothesis that biochemical mechanisms rather than structural changes of the brain underlie the relationship between concurrentPhe-level and sustained attention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 10:49:08