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Titolo:
INHIBITORY EFFECT OF ALL-TRANS-RETINOIC ACID ON THE GROWTH OF FRESHLYISOLATED MYELOMA CELLS VIA INTERFERENCE WITH INTERLEUKIN-6 SIGNAL-TRANSDUCTION
Autore:
OGATA A; NISHIMOTO N; SHIMA Y; YOSHIZAKI K; KISHIMOTO T;
Indirizzi:
OSAKA UNIV,SCH MED,DEPT MED 3,2-2 YAMADAOKA SUITA OSAKA 565 JAPAN OSAKA UNIV,SCH MED,DEPT MED 3 SUITA OSAKA 565 JAPAN
Titolo Testata:
Blood
fascicolo: 9, volume: 84, anno: 1994,
pagine: 3040 - 3046
SICI:
0006-4971(1994)84:9<3040:IEOAAO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE PROMYELOCYTIC LEUKEMIA; MULTIPLE-MYELOMA; DIFFERENTIATION THERAPY; DOWN-REGULATION; EXPRESSION; INVITRO; LINES; ANTIBODIES; METABOLISM; RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
A. Ogata et al., "INHIBITORY EFFECT OF ALL-TRANS-RETINOIC ACID ON THE GROWTH OF FRESHLYISOLATED MYELOMA CELLS VIA INTERFERENCE WITH INTERLEUKIN-6 SIGNAL-TRANSDUCTION", Blood, 84(9), 1994, pp. 3040-3046

Abstract

We showed the dose-dependent growth inhibition by all-trans retinoic acid (ATRA) of myeloma cells freshly isolated from patients. ATRA downregulated the cell surface expression of interleukin-6 receptor (IL-6R) and/or glycoprotein (gp) 130. The growth-inhibitory activity of ATRAwas well correlated with that of anti-gp130 antibody in every sample. Furthermore, ATRA inhibited the production of IL-6 from both myeloma cells and marrow stromal cells, and recombinant IL-6 (rIL-6) could partially recover the myeloma cell growth that had been inhibited by ATRA. These data suggest that ATRA may inhibit the proliferation of myeloma cells both by the downregulation of IL-6R and gp130 expression on myeloma cells and by the inhibition of IL-6 production from myeloma and stromal cells. Prednisolone (PSL) and interferon-gamma (IFN-gamma) also inhibited the myeloma growth, while their effects were different from those of ATRA on IL-6 R and gp130 expression, IL-6 production, and morphological change. The inhibitory effect of ATRA on myeloma cell proliferation was observed in 10 of 14 samples obtained from eight patients, which suggests that ATRA may be a potent new therapeutic agent forsome myeloma patients. (C) 1994 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 04:13:04