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Titolo:
TRANSGANGLIONIC NEUROPEPTIDE-Y RESPONSE TO SCIATIC-NERVE INJURY IN YOUNG AND AGED RATS
Autore:
OHARA S; ROTH KA; BEAUDET LN; SCHMIDT RE;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PATHOL NEUROPATHOL,BOX 8118,660 S EUCLIDAVE ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT PATHOL NEUROPATHOL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT NEUROL ST LOUIS MO 63110
Titolo Testata:
Journal of neuropathology and experimental neurology
fascicolo: 6, volume: 53, anno: 1994,
pagine: 646 - 662
SICI:
0022-3069(1994)53:6<646:TNRTSI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROOT GANGLION NEURONS; PRIMARY SENSORY NEURONS; PRIMARY AFFERENT AXONS; SPINAL-CORD; SUBSTANCE-P; PERIPHERAL AXOTOMY; NUCLEUS GRACILIS; DORSAL HORN; ULTRASTRUCTURAL-CHANGES; GAP-43 EXPRESSION;
Keywords:
AGING; AXOTOMY; GRACILE NUCLEUS; NEUROAXONAL DYSTROPHY; NEUROPEPTIDE Y;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
S. Ohara et al., "TRANSGANGLIONIC NEUROPEPTIDE-Y RESPONSE TO SCIATIC-NERVE INJURY IN YOUNG AND AGED RATS", Journal of neuropathology and experimental neurology, 53(6), 1994, pp. 646-662

Abstract

Gracile neuroaxonal dystrophy (NAD) is a hallmark of the aging human and rodent sensory nervous systems which may represent an abnormal transganglionic response to peripheral axonal injury. To examine the structural plasticity of central dorsal root ganglia (DRG)-derived axons in the gracile nucleus, we evaluated the response of the lumbar DRG andtheir central projections to sciatic nerve injury in young and old rats. In uninjured rats neither the DRG nor its central projections contained histochemical immunoreactivity for neuropeptide Y (NPY). However, within 1 week of sciatic nerve crush or transection injury, NPY immunoreactivity appeared in the lumbar DRG and its central projections, reaching an apparent maximum in number and intensity of processes at 28days. Neuropeptide Y immunoreactivity was more intense and sustained in response to transection compared to crush injury, results supportedby NPY radioimmunoassay. Neuropeptide Y-immunoreactive processes in the gracile nuclei of axotomized young animals consisted of delicate axons or slightly enlarged profiles that may represent regenerative elements. Lumbar dorsal rhizotomy performed simultaneously with sciatic nerve transection prevented the transganglionic NPY response. Dystrophicaxons in the gracile nucleus of non-lesioned aged animals were not NPY-immunoreactive; however, after sciatic nerve transection, NPY immunoreactivity developed in both delicate axons and markedly swollen dystrophic elements, a finding confirmed by ultrastructural immunolocalization. These results establish that despite the presence of NAD in DRG projections to aged gracile nuclei these elements remain capable of a plastic NPY response to peripheral nerve injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 19:14:23