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Titolo:
CYTOSINE-ARABINOSIDE IS NEUROTOXIC TO CHICK-EMBRYO SPINAL-CORD MOTONEURONS IN CULTURE
Autore:
SANZRODRIGUEZ C; BOIX J; COMELLA JX;
Indirizzi:
UNIV LLEIDA,FAC MED,DEPT CIENCIES MED BAS,UNITAT NEUROBIOL MOL,ROVIRAROUTE 44 LLEIDA 25198 SPAIN UNIV LLEIDA,FAC MED,DEPT CIENCIES MED BAS,UNITAT NEUROBIOL MOL LLEIDA25198 SPAIN
Titolo Testata:
Neuroscience letters
fascicolo: 3, volume: 223, anno: 1997,
pagine: 141 - 144
SICI:
0304-3940(1997)223:3<141:CINTCS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
KILLS POSTMITOTIC NEURONS; APOPTOSIS; DEOXYCYTIDINE; SURVIVAL;
Keywords:
MOTONEURONS; MUSCLE EXTRACT; CYTOSINE ARABINOSIDE; CELL DEATH; APOPTOSIS; NITROBENZYLTHIOINOSINE; 2'-DEOXYCYTIDINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
C. Sanzrodriguez et al., "CYTOSINE-ARABINOSIDE IS NEUROTOXIC TO CHICK-EMBRYO SPINAL-CORD MOTONEURONS IN CULTURE", Neuroscience letters, 223(3), 1997, pp. 141-144

Abstract

Cytosine arabinoside (1-beta-D-arabinofuranosylcytosine, AraC) is a commonly used antimitotic agent that kills proliferating cells by inhibiting DNA synthesis. We report that AraC is toxic to cultured chick embryo spinal cord motoneurons (MTNs) in a concentration-dependent fashion with an EC(50) of about 2 mu M. Interestingly, this type of MTN death is specific, resembles that occurring upon muscle extract (MEX) trophic deprivation regarding its morphological and temporal characteristics, and has apoptotic features, as judged by observation of nuclear morphology. The death of AraC-treated MTNs can be blocked by 2'-deoxycytidine (dC), a pyrimidine metabolite AraC is structurally related to. Overall, these findings suggest that dC may participate in a pathway, different from inhibition of DNA synthesis, that is necessary for cultured MTNs to respond to the trophic activities present in MEX. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 12:52:33