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Titolo:
AN ALGORITHM TO DETERMINE PROTEIN-SEQUENCE ALIGNMENT BY UTILIZING DATA OBTAINED FROM A PEPTIDE MIXTURE AND INDIVIDUAL PEPTIDES
Autore:
CAPORALE C; SEPE C; CARUSO C; PETRILLI P; BUONOCORE V;
Indirizzi:
UNIV TUSCIA,DIPARTIMENTO AGROBIOL & AGROCHIM,VIA S CAMILLO LELLIS I-01100 VITERBO ITALY UNIV NAPLES,IST IND AGR I-80138 NAPLES ITALY
Titolo Testata:
Computer applications in the biosciences
fascicolo: 5, volume: 10, anno: 1994,
pagine: 489 - 494
SICI:
0266-7061(1994)10:5<489:AATDPA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPUTER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
CompuMath Citation Index
CompuMath Citation Index
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
C. Caporale et al., "AN ALGORITHM TO DETERMINE PROTEIN-SEQUENCE ALIGNMENT BY UTILIZING DATA OBTAINED FROM A PEPTIDE MIXTURE AND INDIVIDUAL PEPTIDES", Computer applications in the biosciences, 10(5), 1994, pp. 489-494

Abstract

With the aim of limiting peptide purification steps and unambiguouslyascertaining protein sequences, we have designed and implemented on apersonal computer an algorithm to determine sequence alignment by utilizing data obtained from automatic Edman degradation performed on a single peptide mixture and individual peptides. The protein under studyis digested by two different hydrolysis methods and fragments are just isolated from one mixture and sequenced, while the second mixture issubmitted unfractionated to sequence analysis. The algorithm providesfor the exact alignment of the individual peptides using the mixture data for the overlapping. We report an example of application of this approach by utilizing experimental data obtained from a protein of known sequence.

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Documento generato il 25/10/20 alle ore 12:17:08