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Titolo:
EXPRESSION OF CD44 VARIANT TRANSCRIPTS IN DOG LYMPHATIC TISSUE
Autore:
MILDE KF; ALEJANDRO R; PASTORI RL;
Indirizzi:
UNIV MIAMI,SCH MED,DIABET RES INST R134,1450 NW 10TH AVE,POB 016960 MIAMI FL 33101 UNIV MIAMI,SCH MED,DIABET RES INST R134 MIAMI FL 33101
Titolo Testata:
Immunogenetics
fascicolo: 6, volume: 40, anno: 1994,
pagine: 437 - 444
SICI:
0093-7711(1994)40:6<437:EOCVTI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL ACTIVATION; HOMING RECEPTOR; MONOCLONAL-ANTIBODIES; HIGH ENDOTHELIUM; MOLECULE; ADHESION; EXONS; BINDING; RAT; LYMPHOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
K.F. Milde et al., "EXPRESSION OF CD44 VARIANT TRANSCRIPTS IN DOG LYMPHATIC TISSUE", Immunogenetics, 40(6), 1994, pp. 437-444

Abstract

The gene of the CD44 cell surface glycoprotein consists of 20 exons. Ten exons known as variant exons are inserted by alternative RNA splicing between exon 5 and 16, thus generating diversity in the extracellular portion of the protein. We have cloned the dog cDNA homologue of the human variant exon region of CD44 and characterized its transcript expression in normal lymphatic tissues. Using PCR with primers complementary to regions contiguous to the insertion point and a variant exon, all ten variant exons of dog CD44 were detected in a high number of different isoforms. Transcripts containing the ten variable exons directly spliced to both sides of the insertion point were detected. We found an extensive usage of all variant exons from v1 to v10 in a high number of different combinations, some presenting a tissue-specific expression pattern. A similar complex profile of transcript expression was found in peripheral blood lymphocytes from rat and human.

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Documento generato il 02/12/20 alle ore 15:16:04