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Titolo:
LAZAROIDS ENHANCE SKELETAL MYOGENESIS IN PRIMARY CULTURES OF DYSTROPHIN-DEFICIENT MDX MICE
Autore:
METZINGER L; PASSAQUIN AC; VERNIER A; THIRIET N; WARTER JM; POINDRON P;
Indirizzi:
UNIV LOUIS PASTEUR STRASBOURG 1,BIOL & PHARMACOL NEUROMUSCULAIRES LAB,BP 24 F-67401 ILLKIRCH GRAFFENS FRANCE UNIV LOUIS PASTEUR STRASBOURG 1,BIOL & PHARMACOL NEUROMUSCULAIRES LABF-67401 ILLKIRCH GRAFFENS FRANCE UNIV LOUIS PASTEUR STRASBOURG 1,DEPT IMMUNOL IMMUNOPHARMACOL & PATHOLEA1323,NEUROL CLIN 2 F-67401 ILLKIRCH GRAFFENS FRANCE
Titolo Testata:
Journal of the neurological sciences
fascicolo: 2, volume: 126, anno: 1994,
pagine: 138 - 145
SICI:
0022-510X(1994)126:2<138:LESMIP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DUCHENNE MUSCULAR-DYSTROPHY; ACETYLCHOLINE-RECEPTOR EXPRESSION; MUSCLE CELL-CULTURES; LIPID-PEROXIDATION; FREE-RADICALS; VITAMIN-E; MOUSE; PROTEIN; PENICILLAMINE; PREDNISOLONE;
Keywords:
LAZAROIDS; ANTIOXIDANT; MOUSE SKELETAL MUSCLE CULTURES; GLUCOCORTICOIDS; DUCHENNE MUSCULAR DYSTROPHY; DYSTROPHIN DEFICIENCY; MDX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
L. Metzinger et al., "LAZAROIDS ENHANCE SKELETAL MYOGENESIS IN PRIMARY CULTURES OF DYSTROPHIN-DEFICIENT MDX MICE", Journal of the neurological sciences, 126(2), 1994, pp. 138-145

Abstract

Growing evidence suggests a role for free radicals in the degeneration of dystrophin-deficient muscle (as observed in Duchenne muscular dystrophy). We therefore decided to test the action of the lazaroid antioxidant compounds on primary skeletal muscle cell cultures derived froman animal model of Duchenne muscular dystrophy, the mdx mouse. Both vitamin E-derived U-83836E and glucocorticoid-derived U-74389F enhancedmyogenesis of dystrophin-deficient cultures as determined by the number of myotubes, the amount of nicotinic acetylcholine receptor, skeletal muscle alpha-actin levels and myosin light chain. U-83836E enhancedmyogenesis of control congenic C57BL/10 mouse-derived muscle cultureswhereas U-74389F had no detectable effect. This enhanced myogenesis was in most respects similar to the one triggered by alpha-methylprednisolone which is the only drug known to be beneficial in Duchenne muscular dystrophy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 21:01:52