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Titolo:
CYCLOSPORINE-A ENHANCES THE CALCIUM-DEPENDENT INDUCTION OF AP-1 COMPLEX AND C-FOS MESSENGER-RNA IN A T-CELL LYMPHOMA
Autore:
SU QX; EUGSTER HP; RYFFEL B; DUMONT FJ;
Indirizzi:
MERCK & CO INC,MERCK SHARP & DOHME RES LABS,DEPT IMMUNOL RES,POB 2000RAHWAY NJ 07065 MERCK & CO INC,MERCK SHARP & DOHME RES LABS,DEPT IMMUNOL RES RAHWAY NJ 07065 UNIV ZURICH,SWISS FED INST TECHNOL,INST TOXICOL CH-8603 SCHWERZENBACHSWITZERLAND UNIV BASEL,INST PATHOL BASEL SWITZERLAND
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 1, volume: 229, anno: 1996,
pagine: 249 - 256
SICI:
0006-291X(1996)229:1<249:CETCIO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTES-T; CALCINEURIN PHOSPHATASE; INTERFERON-GAMMA; EXPRESSION; ACTIVATION; FK506; CYCLOPHILIN; BINDING; PROTEIN; JUN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
Q.X. Su et al., "CYCLOSPORINE-A ENHANCES THE CALCIUM-DEPENDENT INDUCTION OF AP-1 COMPLEX AND C-FOS MESSENGER-RNA IN A T-CELL LYMPHOMA", Biochemical and biophysical research communications, 229(1), 1996, pp. 249-256

Abstract

The immunosuppressant cyclosporin A (CsA) exerts its pharmacologic actions by inhibiting calcineurin function. Here, we investigated the effect of CsA on the DNA-binding activity of the transcription factor, AP-I, in YAC-1 cells. We found that elevation of intracellular Ca2+ by ionomycin increased AP-I DNA-binding activity in these cells. CsA treatment upregulated the ionomycin-induced, but not the basal AP-1 DNA-binding activity. In contrast, a CsA analog, MeVal(4)CsA, that does not inhibit calcineurin, failed to enhance ionomycin-induced AP-I DNA-binding activity. This activity was shown to involve c-Fos, c-Jun and JunB. CsA consistently augmented ionomycin-induced c-fos mRNA expression and more variably that of JunB. Therefore, calcineurin negatively regulates Ca2+-stimulated AP-1 activity principally at the c-fos induction level. By inhibiting calcineurin, CsA shifts the balance between positive and negative AP-I regulation. Since AP-1 controls the transcription of many genes, this finding may have implications for both the immunosuppressive and toxic effects of CsA. (C) 1996 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 03:02:25