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Titolo:
NEUTROPHILS AND TUMOR-NECROSIS-FACTOR-ALPHA ARE IMPORTANT FOR CONTROLLING EARLY GASTROINTESTINAL STAGES OF EXPERIMENTAL MURINE LISTERIOSIS
Autore:
CONLAN JW;
Indirizzi:
INST BIOL SCI,100 SUSSEX DR OTTAWA ON K1A 0C6 CANADA TRUDEAU INST INC SARANAC LAKE NY 12983
Titolo Testata:
Journal of Medical Microbiology
fascicolo: 3, volume: 46, anno: 1997,
pagine: 239 - 250
SICI:
0022-2615(1997)46:3<239:NATAIF>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCYTOGENES INFECTION; INTRACELLULAR BACTERIA; SECONDARY INFECTION; HOST-RESISTANCE; MICE; CELLS; IMMUNITY; DEFENSE; MECHANISM; LIVER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J.W. Conlan, "NEUTROPHILS AND TUMOR-NECROSIS-FACTOR-ALPHA ARE IMPORTANT FOR CONTROLLING EARLY GASTROINTESTINAL STAGES OF EXPERIMENTAL MURINE LISTERIOSIS", Journal of Medical Microbiology, 46(3), 1997, pp. 239-250

Abstract

The present study examined the need for neutrophils and tumour necrosis factor-alpha (TNF alpha) for early defence against gut infection with the enteroinvasive, facultative intracellular bacterial pathogen, Listeria monocytogenes. Mice were treated with a neutrophil-depleting monoclonal antibody (MAb) or a MAb directed against TNF alpha, and the consequences of these treatments on the course of orally initiated infection with the pathogen were monitored, By day 3, orally initiated L.monocytogenes infection in mice treated with either MAb was severely exacerbated to the extent that up to 5000-fold more listeriae were recovered from the walls of the stomach, small intestine, caecum or largeintestine of treated mice than from controls. Systemic infection resulting from the ingestion of L. monocytogenes was also severely enhanced in mice treated with these MAbs. Therefore, the results showed that neutrophils and TNF alpha have a critical role in the early defence against enteroinvasive L. monocytogenes infection initiated by a natural(in this case the oral) route, as well as in the control of subsequent systemic infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/08/20 alle ore 14:33:15