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Titolo:
2 TYPES OF POLYADENATED MESSENGER-RNAS ARE SYNTHESIZED FROM DROSOPHILA REPLICATION-DEPENDENT HISTONE GENES
Autore:
AKHMANOVA A; MIEDEMA K; KREMER H; HENNIG W;
Indirizzi:
UNIV MAINZ,DEPT PHYSIOL CHEM & PATHOBIOCHEM,DUESBERGWEG 6 D-55128 MAINZ GERMANY CATHOLIC UNIV NIJMEGEN,FAC SCI,DEPT MOL & DEV GENET NL-6525 ED NIJMEGEN NETHERLANDS
Titolo Testata:
European journal of biochemistry
fascicolo: 2, volume: 244, anno: 1997,
pagine: 294 - 300
SICI:
0014-2956(1997)244:2<294:2TOPMA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA DEGRADATION; 3' END FORMATION; STEM-LOOP; 3'-END FORMATION; SEQUENCE; SITE; POLYADENYLATION; EXPRESSION; CLEAVAGE; POLY(A);
Keywords:
HISTONE; POLYADENYLATION; DROSOPHILA; TESTIS; SPERMATOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
A. Akhmanova et al., "2 TYPES OF POLYADENATED MESSENGER-RNAS ARE SYNTHESIZED FROM DROSOPHILA REPLICATION-DEPENDENT HISTONE GENES", European journal of biochemistry, 244(2), 1997, pp. 294-300

Abstract

The polyadenylation of replication-dependent histone H2B, H3 and H4 mRNAs in Drosophila melanogaster was analysed. Two types of mRNAs, containing a poly(A) tail, can be detected in addition to non-polyadenylated messengers, which represent the majority of replication-dependent histone mRNAs. Firstly, conventional polyadenylation signals, localizeddownstream from the stem-loop region, are used to produce polyadenylated mRNAs. The messengers of this type, generated from the D. melanogaster H2B gene, are preferentially synthesized in the testis of the fly. Secondly, a distinct type of polyadenylated histone mRNA has been identified. This mRNA, which is present in many different tissues and constitutes a minor part of the total histone mRNA pool, contains a short poly(A) tail, added to the end of the 3' terminal stem-loop structure, which is in most cases lacking several nucleotides from its 3' end. The sites of polyadenylation within the stem-loop are not preceded bya normal polyadenylation signal. The possible functions of the polyadenylated histone transcripts are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:05:45