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Titolo:
RECOVERY OF TRANSMURAL AND SUBEPICARDIAL WALL THICKENING AFTER SUBENDOCARDIAL INFARCTION
Autore:
HOMANS DC; PAVEK T; LAXSON DD; BACHE RJ;
Indirizzi:
UNIV MINNESOTA,SCH MED,DEPT MED,DIV CARDIOVASC,BOX 375 UMHC MINNEAPOLIS MN 55455
Titolo Testata:
Journal of the American College of Cardiology
fascicolo: 4, volume: 24, anno: 1994,
pagine: 1109 - 1116
SICI:
0735-1097(1994)24:4<1109:ROTASW>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANINE LEFT-VENTRICLE; CORONARY-ARTERY REPERFUSION; MYOCARDIAL-INFARCTION; BLOOD-FLOW; CONSCIOUS DOGS; DEFORMATION; OCCLUSION; THICKNESS; INNER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
D.C. Homans et al., "RECOVERY OF TRANSMURAL AND SUBEPICARDIAL WALL THICKENING AFTER SUBENDOCARDIAL INFARCTION", Journal of the American College of Cardiology, 24(4), 1994, pp. 1109-1116

Abstract

Objectives. This study tested the hypothesis that there is preferential recovery of subepicardial wall thickening after non transmural myocardial infarction. Background. Previous studies have demonstrated gradual recovery of mechanical function after reperfusion in acute myocardial infarction. Because myocardial necrosis is primarily subendocardial, it was hypothesized that recovery of mechanical function would occur primarily in the subepicardial layers. Methods. Eleven mongrel dogs were instrumented with ultrasonic crystals to measure transmural and outer wall thickening. Animals performed treadmill exercise before and 8 days after nontransmural infarction produced by coronary occlusion for 90 min. Results. Coronary artery occlusion reduced myocardial bloodflow to inner layers more than that to outer wall layers (mean [+/-SD] 0.19 +/- 0.35 vs. 0.38 +/- 0.38 mI/g per min, p < 0.05). Infarct size (% of risk region) was also greater in subendocardial layers (33.3 +/- 24.3% inner vs. 8.3 +/- 9.7% outer). Rest transmural wall thickening was 22.4 +/- 7.5% versus 14.4 +/- 6.3% for outer wall layers. Duringcoronary artery occlusion, transmural and outer wall thickening decreased similarly (3.2 +/- 7.7% vs. 0.2 +/- 5.9%). Eight days after reperfusion, thickening of the entire wall recovered to 7.5 +/- 4.7%; however, outer wall thickening had only recovered to 0.0 +/- 5.8%. Myocardial blood flow was abnormal during exercise 8 days after reperfusion, with markedly reduced subendocardial perfusion. However, thickening of the inner and outer layers was similar, with transmural thickening of 8.5 +/- 9.3% and outer wall thickening of 1.6 +/- 6.2%. Conclusions. Despite preferential blood flow and less necrosis, thickening of the outer layer is not preserved 8 days after subendocardial infarction. Theseverity of subendocardial injury appears to be the major determinantof regional function after nontransmural infarction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 18:03:26