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Titolo:
BINDING OF [H-3] (-PN200-110 TO AORTIC MEMBRANES FROM NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS())
Autore:
IKEDA S; AMANO Y; ADACHIAKAHANE S; NAGAO T;
Indirizzi:
UNIV TOKYO,FAC PHARMACEUT SCI,DEPT PHARMACOL & TOXICOL,BUNKYO KU,7-3-1 HONGO TOKYO 113 JAPAN UNIV TOKYO,FAC PHARMACEUT SCI,DEPT PHARMACOL & TOXICOL,BUNKYO KU TOKYO 113 JAPAN
Titolo Testata:
European journal of pharmacology
fascicolo: 2, volume: 264, anno: 1994,
pagine: 223 - 226
SICI:
0014-2999(1994)264:2<223:BO[(TA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN CONVERTING ENZYME; CALCIUM CHANNELS; CHRONIC INHIBITION; BAY K-8644; AGONIST;
Keywords:
SMOOTH MUSCLE; VASCULAR; CA2+ CHANNEL; AORTA; BINDING; [H-3] (+)-PN200-110; SPONTANEOUSLY HYPERTENSIVE RAT (SHR);
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
S. Ikeda et al., "BINDING OF [H-3] (-PN200-110 TO AORTIC MEMBRANES FROM NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS())", European journal of pharmacology, 264(2), 1994, pp. 223-226

Abstract

We report here the quantitative evaluation of binding density (B-max)of [H-3](+)-PN200-110 in aortic membranes obtained from spontaneouslyhypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. At both 4 and 13 weeks of age, there were no significant differences in B-max and the dissociation constants (K-d) of [H-3](+)-PN200-110 binding between SHR and WKY rat aortas. Irrespective of strain, the K-d increased and the B-max decreased with age. These results suggest that thenumber of Ca2+ channels in aortas of SHR and WKY rats are not significantly different, even when hypertension is established in SHR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 22:01:20