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Titolo:
(31)PHOSPHORUS MAGNETIC-RESONANCE SPECTROSCOPY OF THE FRONTAL AND PARIETAL LOBES IN CHRONIC-SCHIZOPHRENIA
Autore:
DEICKEN RF; CALABRESE G; MERRIN EL; MEYERHOFF DJ; DILLON WP; WEINER MW; FEIN G;
Indirizzi:
VET AFFAIRS MED CTR,PSYCHIAT SERV,116-N,4150 CLEMENT ST SAN FRANCISCOCA 94121 VET AFFAIRS MED CTR,MAGNET RESONANCE UNIT SAN FRANCISCO CA 94121 UNIV CALIF SAN FRANCISCO,DEPT RADIOL SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,DEPT MED SAN FRANCISCO CA 00000 UNIV CALIF SAN FRANCISCO,DEPT PSYCHIAT SAN FRANCISCO CA 94143 UNIV MILAN,HS RAFFAELE INST,DEPT PSYCHIAT MILAN ITALY
Titolo Testata:
Biological psychiatry
fascicolo: 8, volume: 36, anno: 1994,
pagine: 503 - 510
SICI:
0006-3223(1994)36:8<503:(MSOTF>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; BRAIN GLUCOSE-METABOLISM; PHOSPHOLIPASE-A2 ACTIVITY; PREFRONTAL CORTEX; INTRACELLULAR PH; P-31; LYSOPHOSPHATIDYLCHOLINE; ACID;
Keywords:
MAGNETIC RESONANCE SPECTROSCOPY; SCHIZOPHRENIA; PHOSPHORUS; PHOSPHOLIPID; FRONTAL LOBE; BRAIN METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
R.F. Deicken et al., "(31)PHOSPHORUS MAGNETIC-RESONANCE SPECTROSCOPY OF THE FRONTAL AND PARIETAL LOBES IN CHRONIC-SCHIZOPHRENIA", Biological psychiatry, 36(8), 1994, pp. 503-510

Abstract

In vivo (31)Phosphorus magnetic resonance spectroscopic imaging (P-31MRSI) was performed on 20 chronic schizophrenic patients and 16 normal controls to determine if there were specific changes in high energy phosphorous and phospholipid metabolism in the frontal lobes of schizophrenic patients. Phosphorous metabolites were assessed in each of theleft and right frontal as well as the left and right parietal lobes. Frontal lobe phosphorous metabolites were also correlated with severity of psychiatric symptomatology as assessed by the Brief Psychiatric Rating Scale (BPRS). Schizophrenics demonstrated higher phosphodiesters(PDE) and lower phosphocreatine (PCr) in both the left and right frontal regions compared to controls. There was also lower left frontal inorganic phosphate (Pi) in the schizophrenic group. No group differences were noted in the left or right parietal regions. In addition, rightfrontal PDE and right frontal PCr were highly correlated with the hostility-suspiciousness and anxiety-depression subscales of the BPRS. This study provides further support for altered frontal lobe phosphorousmetabolism in schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:32:20