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Titolo:
TARGETING OF HUMAN IMMUNODEFICIENCY VIRUS-INFECTED CELLS BY CD8(-LYMPHOCYTES ARMED WITH UNIVERSAL T-CELL RECEPTORS() T)
Autore:
ROBERTS MR; QIN L; ZHANG DZ; SMITH DH; TRAN AC; DULL TJ; GROOPMAN JE; CAPON DJ; BYRN RA; FINER MH;
Indirizzi:
CELL GENESYS INC,322 LAKESIDE DR FOSTER CITY CA 94404 HARVARD UNIV,NEW ENGLAND DEACONESS HOSP,SCH MED,DIV HEMATOL ONCOL BOSTON MA 02215
Titolo Testata:
Blood
fascicolo: 9, volume: 84, anno: 1994,
pagine: 2878 - 2889
SICI:
0006-4971(1994)84:9<2878:TOHIVC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-INFILTRATING LYMPHOCYTES; HUMAN MONOCLONAL-ANTIBODIES; HUMAN ADENOSINE-DEAMINASE; MEDIATED GENE-TRANSFER; LONG-TERM EXPRESSION; HIV-1 NEF PROTEIN; ZETA-CHAIN; SEROPOSITIVE INDIVIDUALS; CYTOTOXIC LYMPHOCYTES; TRANSMEMBRANE PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
M.R. Roberts et al., "TARGETING OF HUMAN IMMUNODEFICIENCY VIRUS-INFECTED CELLS BY CD8(-LYMPHOCYTES ARMED WITH UNIVERSAL T-CELL RECEPTORS() T)", Blood, 84(9), 1994, pp. 2878-2889

Abstract

We have developed an immunotherapeutic approach with potential application in the treatment of viral and malignant disease. We show that primary CD8(+) T cells isolated from peripheral blood can be geneticallymodified by retroviral transduction to express high levels of universal (major histocompatibility complex-unrestricted) chimeric T-cell receptors specific for human immunodeficiency virus (HIV) antigens. Two classes of HIV-specific URs in which the antigen-binding domain is comprised of either CD4 or a single-chain antibody are capable of activating a number of T-cell effector functions in response to target cells, including cytolysis, in a highly sensitive and specific manner. Importantly, we have addressed a number of issues which, although particularly relevant to the clinical application of this approach in the treatment of HIV infection, may also impact on the potential of UR immunotherapy for other disease targets. The UR immunotherapeutic system is particularly suited for evaluation in the clinical setting. (C) 1994 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:52:06