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Titolo:
LACK OF ASSOCIATION BETWEEN CHOLESTEROL AND CORONARY HEART-DISEASE MORTALITY AND MORBIDITY AND ALL-CAUSE MORTALITY IN PERSONS OLDER THAN 70YEARS
Autore:
KRUMHOLZ HM; SEEMAN TE; MERRILL SS; DELEON CFM; VACCARINO V; SILVERMAN DI; TSUKAHARA R; OSTFELD AM; BERKMAN LF;
Indirizzi:
YALE UNIV,SCH MED,DEPT INTERNAL MED,CARDIOVASC MED SECT,333 CEDAR ST,POB 208017 NEW HAVEN CT 06520 YALE UNIV,SCH MED,DEPT EPIDEMIOL & PUBL HLTH,CHRON DIS EPIDEMIOL SECTNEW HAVEN CT 06520 UNIV CONNECTICUT,SCH MED,DIV CARDIOL FARMINGTON CT 00000
Titolo Testata:
JAMA, the journal of the American Medical Association
fascicolo: 17, volume: 272, anno: 1994,
pagine: 1335 - 1340
SICI:
0098-7484(1994)272:17<1335:LOABCA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH BLOOD CHOLESTEROL; UNITED-STATES ADULTS; SERUM-CHOLESTEROL; CARDIOVASCULAR-HEALTH; PLASMA-LIPIDS; RISK-FACTORS; MEN; HYPERCHOLESTEROLEMIA; LIPOPROTEINS; DESIGN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
H.M. Krumholz et al., "LACK OF ASSOCIATION BETWEEN CHOLESTEROL AND CORONARY HEART-DISEASE MORTALITY AND MORBIDITY AND ALL-CAUSE MORTALITY IN PERSONS OLDER THAN 70YEARS", JAMA, the journal of the American Medical Association, 272(17), 1994, pp. 1335-1340

Abstract

Objectives.-To determine whether elevated serum cholesterol level is associated with all-cause mortality, mortality from coronary heart disease, or hospitalization for acute myocardial infarction and unstable angina in persons older than 70 years. Also, to evaluate the association between low levels of high-density lipoprotein cholesterol (HDL-C) and elevated ratio of serum cholesterol to HDL-C with these outcomes. Design.-Prospective, community-based cohort study with yearly interviews. Participants.-A total of 997 subjects who were interviewed in 1988as part of the New Haven, Conn, cohort of the Established Population for the Epidemiologic Study of the Elderly (EPESE) and consented to have blood drawn. Main Outcome Measures.-The risk factor-adjusted odds ratios of the 4-year incidence of all-cause mortality, mortality from coronary heart disease, and hospitalization for myocardial infarction or unstable angina were calculated for the following: subjects with total serum cholesterol levels greater than or equal to 6.20 mmol/L (greater than or equal to 240 mg/dL) compared with subjects with cholesterol levels less than 5.20 mmol/L (<200 mg/dL); subjects in the lowest tertile of HDL-C level compared with those in the highest tertile; and subjects in the highest tertile of the ratio of total serum cholesterolto HDL-C level compared with those in the lowest tertile. Results.-Elevated total serum cholesterol level, low HDL-C, and high total serum cholesterol to HDL-C ratio were not associated with a significantly higher rate of all-cause mortality, coronary heart disease mortality, orhospitalization for myocardial infarction or unstable angina after adjustment for cardiovascular risk factors. The risk factor-adjusted odds ratio for all-cause mortality was 0.99 (95% confidence interval [Cl], 0.56 to 2.69) for the group who had cholesterol levels greater than or equal to 6.20 mmol/L (greater than or equal to 240 mg/dl) compared with the group that had levels less than 5.20 mmol/L (<200 mg/dL); 1.00 (95% Cl, 0.59 to 1.70) for the group in the lowest tertile of HDL-C compared with those in the highest tertile; and 1.03 (95% Cl, 0.62 to 1.71) for subjects in the highest tertile of the ratio of total serum cholesterol to HDL-C compared with those in the lowest tertile. Conclusions.-Our findings do not support the hypothesis that hypercholesterolemia or low HDL-C are important risk factors for all-cause mortality,coronary heart disease mortality, or hospitalization for myocardial infarction or unstable angina in this cohort of persons older than 70 years.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 19:25:33