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Titolo:
PHARMACOGENETIC CHARACTERISTICS OF THE EOSINOPHILIA-MYALGIA-SYNDROME
Autore:
FLOCKHART DA; CLAUW DJ; SALE EB; HEWETT J; WOOSLEY RL;
Indirizzi:
GEORGETOWN UNIV,MED CTR,DEPT MED,DIV CLIN PHARMACOL,ROOM C4001C,MED DENT BLDG WASHINGTON DC 20007 GEORGETOWN UNIV,MED CTR,DEPT MED,DIV RHEUMATOL WASHINGTON DC 20007
Titolo Testata:
Clinical pharmacology and therapeutics
fascicolo: 4, volume: 56, anno: 1994,
pagine: 398 - 405
SICI:
0009-9236(1994)56:4<398:PCOTE>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; DRUG-METABOLISM; S-MEPHENYTOIN; L-TRYPTOPHAN; HYDROXYLATION PHENOTYPE; OXIDATION POLYMORPHISM; ACETYLATOR PHENOTYPE; DEBRISOQUIN; FLUOXETINE; DAPSONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Flockhart et al., "PHARMACOGENETIC CHARACTERISTICS OF THE EOSINOPHILIA-MYALGIA-SYNDROME", Clinical pharmacology and therapeutics, 56(4), 1994, pp. 398-405

Abstract

This study tested the hypothesis that patterns of xenobiotic metabolism in patients with eosinophilia-myalgia syndrome (EMS) differed from healthy control subjects. We determined the genotypes of 27 EMS patients with EMS and 114 control subjects for the cytochrome P450 CYP2D6 polymorphism. The metabolic phenotypes of patients with EMS for S-mephenytoin hydroxylation (n = 17) and dapsone acetylation (n = 19) were determined and compared with 29 healthy control subjects. The incidence of the CYP2D6 poor metabolizer genotype (mutant/mutant) was 0.185 in patients with EMS and 0.061 in control subjects (Mantel-Haenszel, chi(2)= 7.213, p = 0.007). The mephenytoin S/R ratios were 0.39 +/- 0.23 inpatients with EMS versus 0.18 +/- 0.13 in control subjects (p less than or equal to 0.005). There was no difference in dapsone acetylation between the two groups. A pattern of xenobiotic metabolism may play a role in the pathogenesis of EMS, but the precise role that it plays remains unclear.

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Documento generato il 22/01/20 alle ore 12:58:18