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Titolo:
SAFETY, SIDE-EFFECTS AND PATIENT ACCEPTANCE OF THE ANTIANDROGEN CASODEX IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA
Autore:
ERI LM; TVETER KJ;
Indirizzi:
ULLEVAL UNIV HOSP,DEPT SURG,DIV UROL N-0407 OSLO NORWAY
Titolo Testata:
European urology
fascicolo: 3, volume: 26, anno: 1994,
pagine: 219 - 226
SICI:
0302-2838(1994)26:3<219:SSAPAO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIANDROGEN; FLUTAMIDE; CANCER; CARCINOMA; MONOTHERAPY; EXPERIENCE; TRIAL;
Keywords:
PROSTATIC HYPERPLASIA; ANDROGEN ANTAGONISTS, ADVERSE EFFECTS; SEXUAL FUNCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
L.M. Eri e K.J. Tveter, "SAFETY, SIDE-EFFECTS AND PATIENT ACCEPTANCE OF THE ANTIANDROGEN CASODEX IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA", European urology, 26(3), 1994, pp. 219-226

Abstract

Casodex, a new nonsteroidal antiandrogen, was investigated in this double-blind, randomized, placebo-controlled study comprising 28 evaluable patients with benign prostatic hyperplasia, who received Casodex ata dosage of 50 mg daily or a placebo for 24 weeks. The good safety profile of Casodex was confirmed. In common with other nonsteroidal antiandrogens, Casodex was associated with breast enlargement and/or tenderness, being reported by all patients upon direct questioning. A change in sexual function was assessed by two questionnaires, one of them revealing no statistically significant difference between the groups. However, using an alternative questionnaire, approximately half of the patients reported reduced erectile function (p = 0.002), mostly partial, and reduced sexual activity (p = 0.015), whereas libido was well maintained when compared to the placebo. Casodex was not associated withhot flushes. No other side effects of clinical significance were seen, and Casodex was well tolerated by the majority of the patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 03:25:05