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Titolo:
REGIONAL BINDING TO CORTICOTROPIN-RELEASING FACTOR RECEPTORS IN BRAINOF RATS EXPOSED TO CHRONIC COCAINE AND COCAINE WITHDRAWAL
Autore:
AMBROSIO E; SHARPE LG; PILOTTE NS;
Indirizzi:
UNIV NACL EDUC DISTANCIA,DEPT PSICOBIOL E-28040 MADRID SPAIN NIDA,ADDICT RES CTR,DIV INTRAMURAL RES,NEUROSCI LABS BALTIMORE MD 21224
Titolo Testata:
Synapse
fascicolo: 3, volume: 25, anno: 1997,
pagine: 272 - 276
SICI:
0887-4476(1997)25:3<272:RBTCFR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROENDOCRINE RESPONSES; NUCLEUS-ACCUMBENS; LEWIS RATS; BEHAVIORAL-RESPONSES; AMYGDALOID COMPLEX; FACTOR ANTAGONIST; SPRAGUE-DAWLEY; STRESS; CRF; MORPHINE;
Keywords:
I-125 TYR-OCRF; AMYGDALA; CRF(1) RECEPTORS; AUTORADIOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
E. Ambrosio et al., "REGIONAL BINDING TO CORTICOTROPIN-RELEASING FACTOR RECEPTORS IN BRAINOF RATS EXPOSED TO CHRONIC COCAINE AND COCAINE WITHDRAWAL", Synapse, 25(3), 1997, pp. 272-276

Abstract

Cocaine, as does exposure to other physiological stressors, releases brain corticotropin releasing factor (CRF), and this release habituates during the course of repeated cocaine administration in animals. Dueto the many signs of anxiety and responses to stress that are produced by cocaine withdrawal in humans, the present study was designed to assess the effects of chronic cocaine and its withdrawal on regional I-125-Tyr-oCRF binding to the CRF(1) receptor in brains of male Lewis rats. Cocaine or saline was intravenously infused for 10 days in a regimen that resembled a self-administration paradigm (1 mg/kg every 12 minfor 2 h each day). Tissues were harvested either 15 min after or 10 days after the last cocaine infusion, and the brains were sectioned andprepared for CRF(1) receptor autoradiography. Compared with findings in saline controls, there was a 31% lower level of CRF binding sites in the basolateral nucleus of the amygdala immediately after the last cocaine infusion, but not 10 days later. Neuroendocrine and non-neuroendocrine mechanisms associated with CRF(1) receptors do not appear to contribute to long-term withdrawal effects. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:30:41