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Titolo:
THE ROLE OF NITRIC-OXIDE IN THE PATHOGENESIS OF PREECLAMPSIA
Autore:
SELIGMAN SP; BUYON JP; CLANCY RM; YOUNG BK; ABRAMSON SB;
Indirizzi:
NYU,MED CTR,DEPT OBSTET & GYNECOL,DIV MATERNAL FETAL MED,550 1ST AVE NEW YORK NY 10016 NYU,MED CTR,DEPT INTERNAL MED,DIV RHEUMATOL NEW YORK NY 10016
Titolo Testata:
American journal of obstetrics and gynecology
fascicolo: 4, volume: 171, anno: 1994,
pagine: 944 - 948
SICI:
0002-9378(1994)171:4<944:TRONIT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREGNANCY-INDUCED HYPERTENSION; L-ARGININE; RELAXING FACTOR; ENDOTHELIAL-CELLS; RATS; INHIBITION; PATHWAY;
Keywords:
PREECLAMPSIA; NITRIC OXIDE; GREISS REACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
S.P. Seligman et al., "THE ROLE OF NITRIC-OXIDE IN THE PATHOGENESIS OF PREECLAMPSIA", American journal of obstetrics and gynecology, 171(4), 1994, pp. 944-948

Abstract

OBJECTIVE: Nitric oxide, a potent vasodilator released by endothelialcells, inhibits platelet aggregation and adhesion to vascular endothelial surfaces. Because endothelial cell damage is considered pivotal in the pathogenesis of preeclampsia, this study was initiated to determine whether nitric oxide production is decreased in patients with preeclampsia. STUDY DESIGN: Twenty-six patients with preeclampsia (as defined by a blood pressure greater than or equal to 140 mm Hg systolic or90 mm Hg diastolic plus proteinuria, greater than or equal to 300 mg per 24 hours or greater than or equal to 2+ by dipstick, both occurring on two occasions greater than or equal to 4 hours apart) and 26 normotensive women with singleton gestations in the third trimester were studied. Because nitric oxide is spontaneously oxidized to both nitriteand nitrate, two analytic assays were used serially. Serum nitrite levels were initially determined with the Greiss reagent and subsequently analyzed with Escherichia coli nitrate reductase. RESULTS: With the Greiss reagent alone the mean a SEM of serum nitrite level in 26 patients with preeclampsia was significantly decreased compared with 26 normotensive patients (3.46 +/- 1.43 mu mol/L vs 4.65 +/- 0.85 mu mol/L, p = 0.02). With the addition of the nitrate reductase enzyme of Escherichia coli the mean +/- SEM of serum nitrite level in 26 preeclamptic patients was again significantly decreased compared with 26 normotensive patients (20.04 +/- 1.25 mu mol/L vs 27.38 +/- 2.23 mu mol/L, p = 0.02). One patient with the syndrome of hemolysis, elevated liver enzymes, and low platelets demonstrated a concurrent decrease in serum nitrite over a 2-week period, emphasizing the relationship of nitric oxideto the pathophysiologic features of the syndrome. CONCLUSIONS: Circulating levels of nitrite are decreased in patients with preeclampsia. These data support the concept that diminished nitric oxide synthesis contributes to the pathophysiologic changes seen in preeclampsia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 08:17:22