Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ISOLATION OF BIS-INDOLE ALKALOIDS WITH ANTILEISHMANIAL AND ANTIBACTERIAL ACTIVITIES FROM PESCHIERA VAN HEURKII (SYN TABERNAEMONTANA VAN HEURKII)
Autore:
MUNOZ V; MORETTI C; SAUVAIN M; CARON C; PORZEL A; MASSIOT G; RICHARD B; LEMENOLIVER L;
Indirizzi:
IBBA,CP 717 LA PAZ BOLIVIA IBBA LA PAZ BOLIVIA ORSTOM,DEPT SANTE F-75480 PARIS 10 FRANCE FAC PHARM REIMS,CNRS,URA 492,PHARMACOGNOSIE LAB F-51096 REIMS FRANCE
Titolo Testata:
Planta medica
fascicolo: 5, volume: 60, anno: 1994,
pagine: 455 - 459
SICI:
0032-0943(1994)60:5<455:IOBAWA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Keywords:
PESCHIERA VAN HEURKII; TABERNAEMONTANA; APOCYNACEAE; BIS-INDOLE ALKALOIDS; CONODURINE; GABUNINE; CONODURAMINE; LEISHMANICIDAL; ANTIBACTERIAL ACTIVITIES; LEISHMANIA AMAZONENSIS; LEISHMANIA BRAZILIENSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
V. Munoz et al., "ISOLATION OF BIS-INDOLE ALKALOIDS WITH ANTILEISHMANIAL AND ANTIBACTERIAL ACTIVITIES FROM PESCHIERA VAN HEURKII (SYN TABERNAEMONTANA VAN HEURKII)", Planta medica, 60(5), 1994, pp. 455-459

Abstract

Extracts from leaves and stem bark of Pesehiera van heurkii (Muell. Arg. ) L. Allorge (syn. Tabernaemontana van heurkii Muell. Arg., Apocynaceae) have been assayed for antileishmanial and antibacterial activities. The activities were concentrated in the alkaloid fractions which yielded 20 indole and bisindole alkaloids. The strongest leishmanicidal and antibacterial activities were observed with the dimeric alkaloids conodurine (1), N-demethylconodurine (= gabunine) (2), and conoduramine (3). Weak toxicity towards macrophage host cells and strong activity against the intracellular amastigote form of Leishmania were observed for compounds 1 and 2. In vivo, 1 was less active than glucantime (= N-methylglucamine antimonate), the drug of reference, while 2 was devoid of activity at 100 mg/kg.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 15:44:41