Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ACTIVITY OF EXTRACTS OF KIGELIA-PINNATA AGAINST MELANOMA AND RENAL-CARCINOMA CELL-LINES
Autore:
HOUGHTON PJ; PHOTIOU A; UDDIN S; SHAH P; BROWNING M; JACKSON SJ; RETSAS S;
Indirizzi:
UNIV LONDON KINGS COLL,DEPT PHARM,PHARMACOGNOSY RES LABS,MANRESA RD LONDON SW3 6LX ENGLAND CHARING CROSS HOSP,DEPT MED ONCOL,MELANOMA UNIT,CATHERINE GRIFFITHS CANC RES LAB LONDON W6 8RF ENGLAND
Titolo Testata:
Planta medica
fascicolo: 5, volume: 60, anno: 1994,
pagine: 430 - 433
SICI:
0032-0943(1994)60:5<430:AOEOKA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTICANCER AGENTS;
Keywords:
KIGELIA PINNATA; BIGNONIACEAE; GROWTH INHIBITION; MELANOMA; RENAL CARCINOMA; NAPHTHOQUINONES; LAPACHOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
P.J. Houghton et al., "ACTIVITY OF EXTRACTS OF KIGELIA-PINNATA AGAINST MELANOMA AND RENAL-CARCINOMA CELL-LINES", Planta medica, 60(5), 1994, pp. 430-433

Abstract

Serial dilutions of standardised water, ethanol, and dichloromethane extracts of the stembark and fruits of Kigelia pinnata were tested fortheir growth inhibitory effects against four melanoma cell lines and a renal cell carcinoma line (Caki-2) using two different (MTT and SRB)assays. Lapachol, a possible constituent of these extracts, together with known therapeutic antineoplastic agents, was also tested in the same way. The IC50 Of each extract was measured after extracts were diluted to 100 mu g/ml in 1% ethanol or water. Significant inhibitory activity was shown by the dichloromethane extract of the stembark and lapachol (continuous exposure). Moreover, activity was dose-dependent, the extract being less active after 1 h exposure. Chemosensitivity of the melanoma cell lines to the stembark was greater than that seen for the renal adenocarcinoma line. In marked contrast, sensitivity to lapachol was similar amongst the five cell lines. Lapachol was not detectedin the stembark extract.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 14:21:39