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Titolo:
THE EFFECTS OF SUCCIMER ON THE ABSORPTION OF LEAD IN ADULTS DETERMINED BY USING THE STABLE-ISOTOPE PB-204
Autore:
SMITH DR; MARKOWITZ ME; CRICK J; ROSEN JF; FLEGAL AR;
Indirizzi:
UNIV CALIF SAN FRANCISCO,BOX 0843 SAN FRANCISCO CA 94143 UNIV CALIF SANTA CRUZ,WIGS SANTA CRUZ CA 95064 ALBERT EINSTEIN COLL MED,MONTEFIORE MED CTR,DEPT PEDIAT,DIV ENVIRONM SCI BRONX NY 10467
Titolo Testata:
Environmental research
fascicolo: 1, volume: 67, anno: 1994,
pagine: 39 - 53
SICI:
0013-9351(1994)67:1<39:TEOSOT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DITHIOL-CHELATING-AGENTS; X-RAY-FLUORESCENCE; 2,3-DIMERCAPTOSUCCINIC ACID; MESO-2,3-DIMERCAPTOSUCCINIC ACID; METABOLISM; HUMANS; BLOOD; DMSA; INTOXICATION; CHILDREN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
D.R. Smith et al., "THE EFFECTS OF SUCCIMER ON THE ABSORPTION OF LEAD IN ADULTS DETERMINED BY USING THE STABLE-ISOTOPE PB-204", Environmental research, 67(1), 1994, pp. 39-53

Abstract

The chelating agent succimer (meso-2,3-dimercaptosuccinic acid) is orally effective at inducing a urinary lead diuresis and a decrease in blood lead levels in lead poisoned children and adults. However, there are concerns that succimer may increase the absorption of lead from the gastrointestinal (GI) tract during treatment, particularly in cases of continuing lead exposure, which would compromise its effectiveness in reducing whole body lead stores. This preliminary study investigated the effects of succimer on the absorption of lead in adults using a stable lead isotopic tracer. (Pb-204). Twelve male subjects were divided into control (no succimer), 10, and 30 mg succimer/kg body wt treatment groups of 4 individuals each. All subjects ingested a single tracer dose (200 mu g) of Pb-204, followed by a single oral dose of placebo (control) or succimer. Whole blood was collected at intervals of 0, 2, 4, and approximate to 26 hr following ingestion of the Pb-204 tracer, and composite urine and feces samples were collected over the duration of the study (approximate to 26 hr). Mean intestinal excretion of Pb-204 was reduced in the succimer-treated groups compared to the control (placebo), whereas urinary diuresis of Pb-204 was higher in the succimer groups. The amount of lead Pb-204 tracer accounted for at the end of the study was lower in the succimer-treated groups. These results suggest that GI lead absorption was enhanced by succimer and that succimer mediated the redistribution of lead from the circulation to other tissues. However, none of the differences between treatment groups were statistically significant (P < 0.05, t test) because of the relatively large within-group variability. This study demonstrates the utility of microgram doses of a stable lead isotopic tracer to assess the efficacy of clinical chelating agents in humans. Future studies are necessary to further clarify the effects of succimer on the absorption and retention of lead in adults and children. Although, based upon these preliminary data, it appears advisable that patients be maintained in a lead-safe environment while being treated with succimer. (C) 1994 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 19:55:37