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Titolo:
SUPPRESSION OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS BY CANNABINOIDS
Autore:
WIRGUIN I; MECHOULAM R; BREUER A; SCHEZEN E; WEIDENFELD J; BRENNER T;
Indirizzi:
COLUMBIA UNIV,COLL PHYS & SURG,DEPT NEUROL,630 W 168TH ST BB 323 NEW YORK NY 10032 HADASSAH UNIV HOSP,DEPT NEUROL,NEUROIMMUNOL LAB IL-91120 JERUSALEM ISRAEL HEBREW UNIV JERUSALEM,FAC MED,DEPT NAT PROD JERUSALEM ISRAEL
Titolo Testata:
Immunopharmacology
fascicolo: 3, volume: 28, anno: 1994,
pagine: 209 - 214
SICI:
0162-3109(1994)28:3<209:SOEAEB>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; ENANTIOMERIC CANNABINOIDS; DELTA-9-TETRAHYDROCANNABINOL; RECEPTOR; LYMPHOCYTE; RESPONSES; RATS;
Keywords:
CANNABINOIDS; DELTA(8)-TETRAHYDROCANNABINOL; HU-211; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CORTICOSTERONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
I. Wirguin et al., "SUPPRESSION OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS BY CANNABINOIDS", Immunopharmacology, 28(3), 1994, pp. 209-214

Abstract

The effect of Delta(8)-THC on experimental autoimmune encephalomyelitis (EAE) was examined. Delta(8)-THC is an analogue of Delta(9)-THC, the psychoactive component of marijuana. It is more stable and less psychotropic than Delta(9)-THC and like the latter it binds to the brain cannabinoid receptor. Two strains of rats were inoculated for EAE, and Delta(8)-THC (40 mg/kg) was administered for up to 21 days. Delta(8)-THC significantly reduced the incidence and severity of neurological deficit in both rat strains. The beneficial influence of Delta(8)-THC only occurred on oral administration and not with parenteral injection. Serum corticosterone levels were twofold elevated in rats with EAE chronically treated with Delta(8)-THC. These results suggest that suppression of EAE by cannabinoids may be related to their effect on corticosterone secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 11:26:23