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Titolo:
ATIPAMEZOLE, AN ALPHA(2), ANTAGONIST, AUGMENTS OPIATE-INDUCED MUSCLE RIGIDITY IN THE RAT
Autore:
WEINGER MB; BEDNARCZYK JM;
Indirizzi:
VET AFFAIRS MED CTR,OPIATE NEUROPHARMACOL RES LAB,3350 LA JOLLA VILLAGE DR SAN DIEGO CA 92161 UNIV CALIF SAN DIEGO,DEPT ANESTHESIOL SAN DIEGO CA 92103
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 3, volume: 49, anno: 1994,
pagine: 523 - 529
SICI:
0091-3057(1994)49:3<523:AAAAAO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED MUSCULAR RIGIDITY; ALPHA-2-ADRENOCEPTOR ANTAGONIST; CLONIDINE ANALGESIA; MEDIATED INHIBITION; LOCUS COERULEUS; CROSS-TOLERANCE; MU-RECEPTOR; DEXMEDETOMIDINE; AGONIST; BRAIN;
Keywords:
MUSCLE TONE; ALPHA(2)-ADRENERGIC ANTAGONIST; ATIPAMEZOLE; OPIATE; MUSCLE RIGIDITY; ALFENTANIL; DEXMEDETOMIDINE; ANESTHESIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
M.B. Weinger e J.M. Bednarczyk, "ATIPAMEZOLE, AN ALPHA(2), ANTAGONIST, AUGMENTS OPIATE-INDUCED MUSCLE RIGIDITY IN THE RAT", Pharmacology, biochemistry and behavior, 49(3), 1994, pp. 523-529

Abstract

Atipamezole is a new, highly selective alpha(2) adrenoceptor antagonist currently undergoing clinical trials as an antagonist for dexmedetomidine, a potent alpha(2) agonist with sedative and analgesic properties. It has previously been demonstrated that dexmedetomidine, acting at central alpha(2) adrenoceptors, antagonizes opiate-induced muscle rigidity. However, the role of endogenous alpha(2)-adrenergic systems inopiate-induced rigidity remains to be elucidated. The present study was designed to assess the effects of atipamezole on basal muscle tone and on alfentanil-induced muscle rigidity in the rat. Muscle tone was measured using gastrocnemius electromyography (EMG). After a 15-min baseline, saline or atipamezole (0.3 or 1.0 mg/kg) was administered, and10 min later, saline or alfentanil (50, 150, or 300 mu g/kg) was injected subcutaneously. Data were collected for an additional 60 min. Atipamezole (1.0 mg/kg) pretreatment (in the absence of alfentanil) produced a small increase in tonic EMG activity when compared with saline pretreatment. After saline pretreatment, significant muscle rigidity occurred in the two highest alfentanil dose groups. Atipamezole (0.3 and1.0 mg/kg) augmented alfentanil-induced muscle rigidity. The ability of the alpha(2) antagonist to potentiate both basal muscle tone and alfentanil-induced rigidity suggests that endogenous adrenergic activityand/or direct alpha(2)-adrenoceptor interaction with opioid receptorsmediate opiate-induced muscle rigidity. These findings may be of clinical as well as basic neuropharmacological interest.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:39:51