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Titolo:
INTRASTRIATAL RO15-4513 FUNCTIONALLY ANTAGONIZES ETHANOL-INDUCED MOTOR INCOORDINATION AND STRIATAL ADENOSINERGIC MODULATION OF ETHANOL-INDUCED MOTOR INCOORDINATION IN RATS
Autore:
MENG ZH; DAR MS;
Indirizzi:
E CAROLINA UNIV,SCH MED,DEPT PHARMACOL GREENVILLE NC 27858 E CAROLINA UNIV,SCH MED,DEPT PHARMACOL GREENVILLE NC 27858
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 1, volume: 271, anno: 1994,
pagine: 524 - 534
SICI:
0022-3565(1994)271:1<524:IRFAEM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC ACID; CENTRAL-NERVOUS-SYSTEM; SHORT-SLEEP MICE; CEREBELLAR SYNAPTOSOMES; LOCOMOTOR-ACTIVITY; BINDING-SITES; LONG-SLEEP; RO 15-4513; PLUS-MAZE; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
Z.H. Meng e M.S. Dar, "INTRASTRIATAL RO15-4513 FUNCTIONALLY ANTAGONIZES ETHANOL-INDUCED MOTOR INCOORDINATION AND STRIATAL ADENOSINERGIC MODULATION OF ETHANOL-INDUCED MOTOR INCOORDINATION IN RATS", The Journal of pharmacology and experimental therapeutics, 271(1), 1994, pp. 524-534

Abstract

To study the role of the striatum in modulating the effects of adenosine agonists and benzodiazepine inverse agonists on acute ethanol-induced motor impairment, we evaluated the effect of direct intrastriatal Ro15-4513 [0.625, 1.25 and 2.5 ng], a partial inverse agonist of benzodiazepine receptor, on ethanol-induced motor incoordination. A significant and nearly dose-dependent antagonism by Ro15-4513 was observed, which suggests involvement of the striatum in ethanol-induced motor incoordination. No effect of IST Ro15-4513 on motor incoordination induced by Na-pentobarbital (10 mg/kg, i.p.) was noted, indicating the selectivity of the antiethanol action of Ro15-4513. The IST adenosine agonist N-6-cyclohexyladenosine (CHA) markedly accentuated ethanol-induced motor incoordination in a dose-related manner, suggesting a striatal adenosinergic modulation of ethanol-induced motor incoordination. The IST Ro15-4513 also significantly antagonized the accentuating effects of CHA on ethanol-induced motor incoordination. No change in normal motor coordination was observed after IST CHA or Ro15-4513 when followed by saline administration instead of ethanol. No accentuating effect byintrahippocampal CHA on ethanol-induced motor incoordination was seen, which suggests the selectivity of striatal adenosinergic modulation of ethanol-induced motor incoordination. There was no significant radioactivity present in the systemic circulation, in the CSF or in brain areas other than striatum after intrastriatal [H-3]Ro15-4513 or [H-3]CHA and ethanol injection. Data obtained so far support the involvementof striatum in ethanol's ataxia as well as striatal adenosinergic modulation of the central effect(s) of ethanol, possibly through Ro15-4513-sensitive mechanism(s).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:20:11