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Titolo:
INHIBITION OF TH1 RESPONSES PREVENTS INFLAMMATORY BOWEL-DISEASE IN SCID MICE RECONSTITUTED WITH CD45RB(HI) CD4(-CELLS() T)
Autore:
POWRIE F; LEACH MW; MAUZE S; MENON S; CADDLE LB; COFFMAN RL;
Indirizzi:
DNAX RES INST MOLEC & CELLULAR BIOL INC,901 CALIF AVE PALO ALTO CA 94040 SCHERING PLOUGH CORP,RES INST LAFAYETTE NJ 07848
Titolo Testata:
Immunity
fascicolo: 7, volume: 1, anno: 1994,
pagine: 553 - 562
SICI:
1074-7613(1994)1:7<553:IOTRPI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; INTESTINAL EPITHELIAL MONOLAYERS; INTERLEUKIN-10 PROTECTS MICE; INTERFERON-GAMMA PRODUCTION; IFN-GAMMA; BOWEL-DISEASE; CYTOKINE PRODUCTION; MONOCLONAL-ANTIBODIES; ULCERATIVE-COLITIS; FACTOR CACHECTIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
F. Powrie et al., "INHIBITION OF TH1 RESPONSES PREVENTS INFLAMMATORY BOWEL-DISEASE IN SCID MICE RECONSTITUTED WITH CD45RB(HI) CD4(-CELLS() T)", Immunity, 1(7), 1994, pp. 553-562

Abstract

We have described a murine model of IBD that was induced in C.B-17 scid mice by transfer of the CD45RB(hi) subpopulation of CD4(+) T cells from normal BALB/c mice and could be prevented by cotransfer of the CD45RB(lo) CD4(+) T cell subset. Here we have dissected the mechanism ofpathogenesis of IBD in this model and used this information for rational immunotherapy of the disease. CD4(+) cells from diseased mice displayed a highly polarized Th1 pattern of cytokine synthesis upon polyclonal stimulation in vitro. The administration of anti-IFN gamma MAb tomice soon after T cell transfer prevented development of colitis for up to 12 weeks. Continual neutralization of TNF with anti-TNF MAbs reduced the incidence of severe disease; however, neutralization of TNF during only the first 3-4 weeks had no effect. Severe colitis was completely abrogated in mice treated systemically with rlL-10, but not withrlL-4.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 23:10:43