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Titolo:
PARASIGHT(R)F TEST COMPARED WITH THE POLYMERASE CHAIN-REACTION AND MICROSCOPY FOR THE DIAGNOSIS OF PLASMODIUM-FALCIPARUM MALARIA IN TRAVELERS
Autore:
HUMAR A; OHRT C; HARRINGTON MA; PILLAI D; KAIN KC;
Indirizzi:
TORONTO HOSP,TROP DIS UNIT,DEPT MED,DIV INFECT DIS,200 ELIZABETH ST,EN G-224 TORONTO ON M5G 2C4 CANADA TORONTO HOSP,TROP DIS UNIT,DEPT MED,DIV INFECT DIS TORONTO ON M5G 2C4CANADA WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV EXPT THERAPEUTWASHINGTON DC 20307 UNIV TORONTO TORONTO ON M5S 1A1 CANADA
Titolo Testata:
The American journal of tropical medicine and hygiene
fascicolo: 1, volume: 56, anno: 1997,
pagine: 44 - 48
SICI:
0002-9637(1997)56:1<44:PTCWTP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIGEN-CAPTURE ASSAY; IMPORTED MALARIA; IDENTIFICATION; INFECTIONS; VIVAX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
A. Humar et al., "PARASIGHT(R)F TEST COMPARED WITH THE POLYMERASE CHAIN-REACTION AND MICROSCOPY FOR THE DIAGNOSIS OF PLASMODIUM-FALCIPARUM MALARIA IN TRAVELERS", The American journal of tropical medicine and hygiene, 56(1), 1997, pp. 44-48

Abstract

Imported malaria is an increasing problem worldwide. A rapid and accurate test for Plasmodium falciparum infection would facilitate the diagnosis of malaria in the returned traveler The ParaSight(R)F antigen capture assay (dipstick test) is a new diagnostic test for P. falciparum based on detection of circulating histidine-rich protein-2 antigen. We performed a blinded evaluation of this assay compared with microscopy and the polymerase chain reaction (PCR) for the detection of P. falciparum infection in 151 febrile travelers. Compared with the PCR, thedipstick test had a sensitivity of 88% and a specificity of 97%. The ability of the dipstick test to detect P. falciparum was similar with that of microscopy (88% versus 83%) since the species of Plasmodium in14 of 133 malaria-infected patients could not be determined by microscopy due to low parasite numbers. The dipstick test was 40% sensitive for infections with < 50 parasites/mu l, 89% with 50-100 parasites/mu l, and greater than or equal to 93% with > 100 parasites/mu l. Circulating antigen was detectable in 68% of the patients seven days after initiation of treatment and in 27% at day 28. The dipstick test represents a simple and accurate test for the diagnosis of P. falciparum infection in the returned traveler.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 09:21:29