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Titolo:
SALMONELLA-TYPHIMURIUM INVASION OF EPITHELIAL-CELLS - ROLE OF INDUCEDHOST-CELL TYROSINE PROTEIN-PHOSPHORYLATION
Autore:
ROSENSHINE I; RUSCHKOWSKI S; FOUBISTER V; FINLAY BB;
Indirizzi:
UNIV BRITISH COLUMBIA,DEPT BIOCHEM & MOLEC BIOL,BIOTECHNOL LAB VANCOUVER V6T 1Z3 BC CANADA UNIV BRITISH COLUMBIA,DEPT BIOCHEM & MOLEC BIOL,BIOTECHNOL LAB VANCOUVER V6T 1Z3 BC CANADA UNIV BRITISH COLUMBIA,DEPT MICROBIOL & IMMUNOL VANCOUVER V6T 1Z3 BC CANADA
Titolo Testata:
Infection and immunity
fascicolo: 11, volume: 62, anno: 1994,
pagine: 4969 - 4974
SICI:
0019-9567(1994)62:11<4969:SIOE-R>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; SIGNAL-TRANSDUCTION; BACTERIAL UPTAKE; RECEPTOR; MUTANTS; KINASE; ENTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
I. Rosenshine et al., "SALMONELLA-TYPHIMURIUM INVASION OF EPITHELIAL-CELLS - ROLE OF INDUCEDHOST-CELL TYROSINE PROTEIN-PHOSPHORYLATION", Infection and immunity, 62(11), 1994, pp. 4969-4974

Abstract

Salmonella typhimurium invades nonphagocytic epithelial and fibroblast cells via a process resembling phagocytosis. We have compared some phenotypes that are involved in S. typhimurium invasion by using different host cell lines, including HeLa, Henle-407, and A431. Infection with either wild-type S. typhimurium, bacterial culture supernatant, or the noninvasive invA mutant was associated with induction of tyrosine phosphorylation of host cell mitogenic activating protein kinase. However, we did not detect induction of tyrosine phosphorylation of the epidermal growth factor receptor in S. typhimurium-infected cells. Treatment with the tyrosine protein kinase inhibitor genistein did not reduce S. typhimurium invasion into any of these cell lines. These resultssuggest that S. typhimurium invasion is independent of host cell epidermal growth factor receptor activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 07:43:32